caa a22 4500 469054646 CHVBK 20180323132840.0 cr unu---uuuuu 170328e19921101xx s 000 0 eng 10.1007/BF00243502 doi (NATIONALLICENCE)springer-10.1007/BF00243502 Changes in the fibrinolytic system associated with physical conditioning [Elektronische Daten] [J. De Paz, J. Lasierra, J. Villa, E. Viladés, M. Martín-Nuño, J. González-Gallego] Summary: The effects of physical conditioning on plasma fibrinolytic activity were studied in two groups of subjects. Volunteers not engaged in any sport were compared with individuals having been subjected to aerobic conditioning (middle-distance runners, defined as men running more than 80 km per week). Plasma concentrations of the different components of the fibrinolytic system were evaluated before and immediately after a maximal effort treadmill protocol. Comparison of the resting parameters revealed that under basal conditions for plasma concentrations of plasminogen, fibrinogen, α2-antiplasmin, protein C and protein S there were no differences between the two groups. Concentrations of the fibrin degradation products (FbDP) and fibrinogen degradation products (FgDP) were significantly higher in the runners than in the control group, indicating an increased fibrinolytic potential that seemed to be a consequence of the reduced formation of tissue plasminogen activator-plasminogen activator inhibitor (t-PA-PAI) complexes. Acute maximal exercise resulted in pronounced fibrinolysis, evidenced by the elevation of FbDP and FgDP concentrations, in both groups of subjects. The acceleration of the fibrinolytic activity was larger in conditioned individuals, which could be accounted for by a higher t-PA release and reduced formation of t-PA-PAI complexes when compared to the untrained subjects. Springer-Verlag, 1992 Aerobic conditioning nationallicence Fibrinolytic activity nationallicence Tissue plasminogen activator nationallicence Tissue plasminogen activator inhibitor nationallicence De Paz J. Institute of Physical Education, University of León, León, Spain aut Lasierra J. Service of Hematology, San Millán Hospital, Logroño, Spain aut Villa J. Institute of Physical Education, University of León, León, Spain aut Viladés E. Service of Hematology, San Millán Hospital, Logroño, Spain aut Martín-Nuño M. Service of Hematology, San Millán Hospital, Logroño, Spain aut González-Gallego J. Department of Physiology, Pharmacology and Toxicology, University of León, Campus Universitario, E-24071, León, Spain aut European Journal of Applied Physiology and Occupational Physiology Springer-Verlag 65/5(1992-11-01), 388-393 0301-5548 65:5<388 1992 65 421 https://doi.org/10.1007/BF00243502 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00243502 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- De Paz J. Institute of Physical Education, University of León, León, Spain aut NATIONALLICENCE 700 1- Lasierra J. Service of Hematology, San Millán Hospital, Logroño, Spain aut NATIONALLICENCE 700 1- Villa J. Institute of Physical Education, University of León, León, Spain aut NATIONALLICENCE 700 1- Viladés E. Service of Hematology, San Millán Hospital, Logroño, Spain aut NATIONALLICENCE 700 1- Martín-Nuño M. Service of Hematology, San Millán Hospital, Logroño, Spain aut NATIONALLICENCE 700 1- González-Gallego J. Department of Physiology, Pharmacology and Toxicology, University of León, Campus Universitario, E-24071, León, Spain aut NATIONALLICENCE 773 0- European Journal of Applied Physiology and Occupational Physiology Springer-Verlag 65/5(1992-11-01), 388-393 0301-5548 65:5<388 1992 65 421 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer