caa a22 4500 469054786 CHVBK 20180323132840.0 cr unu---uuuuu 170328e19920301xx s 000 0 eng 10.1007/BF00705065 doi (NATIONALLICENCE)springer-10.1007/BF00705065 Normotensive normoxic men undergoing water diuresis fail to respond to stimulation of their peripheral arterial chemoreceptors by almitrine with an increase in plasma concentrations of atrial natriuretic factor [Elektronische Daten] [C. Ledderhos, W. Quies, A. Bub, R. Sanchez] Summary: The purpose of this study was to investigate the possible participation of atrial natriuretic factor (ANF) in the natriuretic and diuretic response occurring after stimulation of the peripheral arterial chemoreceptors by almitrine bismesylate in normoxic humans. The experiments were performed in 14 healthy male volunteers undergoing water diuresis. Each subject participated in two experiments. In one of them they ingested 100-mg almitrine at 12 p.m. The other study served as a control. Surprisingly, our subjects responded to almitrine with an elevation of urine flow only, whereas sodium excretion remained almost unchanged over the whole period of the experiments. As regards ANF plasma concentrations, no statistically significant differences between the control and the almitrine group could be observed. Moreover, no direct connection between ANF plasma concentrations and renal volume excretion was detectable. We concluded that a specific stimulation of peripheral arterial chemoreceptors by almitrine in humans undergoing water diuresis did not seem to raise ANF plasma concentrations as is the case at high altitude. Therefore we would suggest that there exists no specific reflex influence of these receptors on ANF release. Springer-Verlag, 1992 Peripheral arterial chemoreceptors nationallicence Almitrine nationallicence High altitude hypoxia nationallicence Atrial natriuretic factor nationallicence Kidney function nationallicence Ledderhos C. Institute of Physiology, Ernst-Moritz-Arndt-University, Rubenowstrasse 3, 0-2200, Greifswald, Germany aut Quies W. Institute of Physiology, Ernst-Moritz-Arndt-University, Rubenowstrasse 3, 0-2200, Greifswald, Germany aut Bub A. Lower Saxony Institute of Peptide Research (IPF), Feodor-Lynen-Str. 31, W-3000, Hannover 61, Germany aut Sanchez R. Institute of Physiology, Ernst-Moritz-Arndt-University, Rubenowstrasse 3, 0-2200, Greifswald, Germany aut European Journal of Applied Physiology and Occupational Physiology Springer-Verlag 65/2(1992-03-01), 104-109 0301-5548 65:2<104 1992 65 421 https://doi.org/10.1007/BF00705065 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00705065 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ledderhos C. Institute of Physiology, Ernst-Moritz-Arndt-University, Rubenowstrasse 3, 0-2200, Greifswald, Germany aut NATIONALLICENCE 700 1- Quies W. Institute of Physiology, Ernst-Moritz-Arndt-University, Rubenowstrasse 3, 0-2200, Greifswald, Germany aut NATIONALLICENCE 700 1- Bub A. Lower Saxony Institute of Peptide Research (IPF), Feodor-Lynen-Str. 31, W-3000, Hannover 61, Germany aut NATIONALLICENCE 700 1- Sanchez R. Institute of Physiology, Ernst-Moritz-Arndt-University, Rubenowstrasse 3, 0-2200, Greifswald, Germany aut NATIONALLICENCE 773 0- European Journal of Applied Physiology and Occupational Physiology Springer-Verlag 65/2(1992-03-01), 104-109 0301-5548 65:2<104 1992 65 421 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer