caa a22 4500 469054883 CHVBK 20180323132840.0 cr unu---uuuuu 170328e19920301xx s 000 0 eng 10.1007/BF00705068 doi (NATIONALLICENCE)springer-10.1007/BF00705068 Effects of whole body microwave exposure on the rat brain contents of biogenic amines [Elektronische Daten] [Ryoichi Inaba, Kei-ichi Shishido, Akira Okada, Takashi Moroji] Summary: The effects of whole body microwave exposure on the central nervous system (CNS) of the rat were investigated. Rats weighing from 250 to 320 g were exposed for 1 h to whole body microwave with a frequency of 2450 MHz at power densities of 5 and 10 mW·cm−2 at an ambient temperature of 21-23°C. The rectal temperatures of the rats were measured just before and after microwave exposure and mono-amines and their metabolites in various discrete brain regions were determined after microwave exposure. Microwave exposure at power densities of 5 and 10 mW·cm−2 increased the mean rectal temperature by 2.3°C and 3.4°C, respectively. The noradrenaline content in the hypothalamus was significantly reduced after microwave exposure at a power density of 10 mW·cm−2. There were no differences in the dopamine (DA) content of any region of the brain between microwave exposed rats and control rats. The dihydroxyphenyl acetic acid (DOPAC) content, the main metabolite of DA, was significantly increased in the pons plus medulla oblongata only at a power density of 10 mW·cm−2. The DA turnover rates, the DOPAC:DA ratio, in the striatum and cerebral cortex were significantly increased only at a power density of 10 mW·cm−2 The serotonin (5-hydroxytryptamine, 5-HT) content in all regions of the brain of microwave exposed rats was not different from that of the control rats. The 5-hydroxyindoleacetic acid (5-HIAA) content in the cerebral cortex of microwave exposed rats was significantly increased at power densities of 5 and 10 mW·cm−2. The 5-HT turnover rates and the 5-HIAA:5-HT ratio were significantly increased in the cerebral cortex at a power density of 5 mW·cm−2. Significant increases in the 5-HT turnover rate were observed in the pons plus medulla oblongata and hypopthalamus at a power density of 10 mW·cm−2. These results indicated that whole body microwave exposure with a frequency of 2450 MHz at power densities of 5 and 10 mW·cm−2 affected the function of mono-aminergic neurons in the rat brain. It would seem that the effects of whole body microwave exposure on the CNS can be attributed to the hyperthermia characteristic of microwave exposure, although the direct effects of microwave irradiation on the CNS cannot be completely discarded. Springer-Verlag, 1992 Microwave nationallicence Biogenic amines nationallicence Brain nationallicence Rat nationallicence Hyperthermia nationallicence Inaba Ryoichi Department of Public Health, School of Medicine, Kanazawa University, 13-1 Takara-machi, 920, Kanazawa, Japan aut Shishido Kei-ichi Department of Public Health, School of Medicine, Kanazawa University, 13-1 Takara-machi, 920, Kanazawa, Japan aut Okada Akira Department of Public Health, School of Medicine, Kanazawa University, 13-1 Takara-machi, 920, Kanazawa, Japan aut Moroji Takashi Department of Psychopharmacology, Psychiatric Research Institute of Tokyo, 2-l-8 Kamikitazawa, 156, Setagaya Ward, Tokyo, Japan aut European Journal of Applied Physiology and Occupational Physiology Springer-Verlag 65/2(1992-03-01), 124-128 0301-5548 65:2<124 1992 65 421 https://doi.org/10.1007/BF00705068 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00705068 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Inaba Ryoichi Department of Public Health, School of Medicine, Kanazawa University, 13-1 Takara-machi, 920, Kanazawa, Japan aut NATIONALLICENCE 700 1- Shishido Kei-ichi Department of Public Health, School of Medicine, Kanazawa University, 13-1 Takara-machi, 920, Kanazawa, Japan aut NATIONALLICENCE 700 1- Okada Akira Department of Public Health, School of Medicine, Kanazawa University, 13-1 Takara-machi, 920, Kanazawa, Japan aut NATIONALLICENCE 700 1- Moroji Takashi Department of Psychopharmacology, Psychiatric Research Institute of Tokyo, 2-l-8 Kamikitazawa, 156, Setagaya Ward, Tokyo, Japan aut NATIONALLICENCE 773 0- European Journal of Applied Physiology and Occupational Physiology Springer-Verlag 65/2(1992-03-01), 124-128 0301-5548 65:2<124 1992 65 421 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer