caa a22 4500 469054948 CHVBK 20180323132840.0 cr unu---uuuuu 170328e19920301xx s 000 0 eng 10.1007/BF00705074 doi (NATIONALLICENCE)springer-10.1007/BF00705074 Adaptations in skeletal muscle capillarity following changes in oxygen supply and changes in oxygen demands [Elektronische Daten] [Gregory Snyder, Caroline Farrelly, Joseph Coelho] Summary: The effects of changes in oxygen supply and oxygen demands on fiber cross-sectional areas, capillary dersities and capillary to fiber ratios were determined in three skeletal muscles of rat. The muscles examined were the vastus lateralis, soleus, and diaphragm. Reduced oxygen supply was produced by subjecting rats to ambient hypoxia, and increased oxygen demands were produced by subjecting rats to low ambient temperatures or treatment with thyroxin. Capillaries were visualized by injecting fluorescent dyes into the circulation. Muscles were quick frozen at resting lengths to preserve normal fiber geometry and were subsequently sectioned on a cryostat. All of the muscles sampled from animals in the experimental groups had elevated capillary densities. However, capillary to fiber ratios were not increased significantly in any muscle, for any experimental condition. Thus, all of the observed differences in capillarity were due to changes in the intrinsic rate of muscle fiber growth. Further, the relations of capillary density and capillary to fiber ratio to fiber area were the same as those obtained during normal maturation, suggesting that capillary growth is closely linked to the intrinsic rate of fiber growth. Springer-Verlag, 1992 Microvasculature nationallicence Capillary growth nationallicence Cold nationallicence Hypoxia nationallicence Thyroxin nationallicence Snyder Gregory Department of EPO Biology, University of Colorado, 80309-0334, Boulder, CO, USA aut Farrelly Caroline Department of EPO Biology, University of Colorado, 80309-0334, Boulder, CO, USA aut Coelho Joseph Department of EPO Biology, University of Colorado, 80309-0334, Boulder, CO, USA aut European Journal of Applied Physiology and Occupational Physiology Springer-Verlag 65/2(1992-03-01), 158-163 0301-5548 65:2<158 1992 65 421 https://doi.org/10.1007/BF00705074 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00705074 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Snyder Gregory Department of EPO Biology, University of Colorado, 80309-0334, Boulder, CO, USA aut NATIONALLICENCE 700 1- Farrelly Caroline Department of EPO Biology, University of Colorado, 80309-0334, Boulder, CO, USA aut NATIONALLICENCE 700 1- Coelho Joseph Department of EPO Biology, University of Colorado, 80309-0334, Boulder, CO, USA aut NATIONALLICENCE 773 0- European Journal of Applied Physiology and Occupational Physiology Springer-Verlag 65/2(1992-03-01), 158-163 0301-5548 65:2<158 1992 65 421 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer