caa a22 4500 46905557X CHVBK 20180323132842.0 cr unu---uuuuu 170328e19920701xx s 000 0 eng 10.1007/BF00636226 doi (NATIONALLICENCE)springer-10.1007/BF00636226 Met-enkephalin, β-endorphin and cortisol responses to sub-maximal exercise after sleep disturbances [Elektronische Daten] [F. Mougin, M. Simon-Rigaud, C. Mougin, H. Bourdin, M. Jacquier, M. Henriet, D. Davenne, J. Kantelip, P. Magnin, R. Gaillard] Summary: The present study compared the effects of partial sleep deprivation and the effects of an intake of a hypnotic compound (zolpidem) prior to bedtime, on sleep and on hormonal and metabolic adaptations to subsequent exercise. Sleep deprivation consisted of a delayed bedtime and an early getting-up time. Eight young subjects, who slept well and were highly trained athletes, were enrolled in this study. Sleep was recorded polygraphically and the following afternoon exercise was performed on a cycle ergometer for 30 min at 75% of maximal oxygen consumption (VO2max) after a 10-min warm up. Met-enkephalin, β-endorphin, cortisol, and lactate concentrations were measured at rest and during exercise. The data obtained after experimental sleep, with and without medication were compared with those obtained in the reference condition with normal sleep. Both types of sleep reduction decreased the total sleep time, stage 2 sleep, and rapid eye movement sleep, whereas zolpidem administration did not modify either the duration of sleep or the sleep stages. After the reference night, plasma met-enkephalin did not show any significant change at the end of the submaximal exercise, whereas β-endorphin, cortisol, and lactic acid concentrations increased significantly in all subjects. The changes in concentration in β-endorphin were significantly related to the changes in cortisol (r=0.78;P<0.01) and to the changes in plasma lactic acid (r=0.58;P<0.05). Cortisol concentrations were also related to lactic acid values (r=0.94;P<0.01). Partial sleep loss altered lactate concentrations during submaximal exercise but did not affect the hormonal levels of met-enkephalin, β-endorphin and cortisol in the blood. Zolpidem administration failed to change lactate and hormone concentrations. These results suggested that partial sleep deprivation may have contributed to the changes in metabolic responses without significantly altering the hormonal response to exercise. Zolpidem intake did not impair the response of different variables to exercise the following day. Springer-Verlag, 1992 Sleep nationallicence Zolpidem nationallicence Met-enkephalin nationallicence β-Endorphin nationallicence Cortisol nationallicence Lactate nationallicence Mougin F. Service de Physiopathologie Respiratoire et Cérébrale, Médecine et Biologie du Sport, CHU F-25030, Besançon Cedex, France aut Simon-Rigaud M. Service de Physiopathologie Respiratoire et Cérébrale, Médecine et Biologie du Sport, CHU F-25030, Besançon Cedex, France aut Mougin C. Laboratoire de Virologie, CHU F-25030, Besançon Cedex, France aut Bourdin H. Service de Physiopathologie Respiratoire et Cérébrale, Médecine et Biologie du Sport, CHU F-25030, Besançon Cedex, France aut Jacquier M. Clinique Médicale, Hôpital Cantonal Universitaire, CH-1211, Genéve, Switzerland aut Henriet M. Laboratoire d'Explorations Fonctionnelles Métaboliques et Rénales, CHU F-25 030, Besançon Cedex, France aut Davenne D. Laboratoire d'Etudes et de Recherches sur la Performance Sportive, UFR-STAPS, BP 138, F-21004, Dijon Cedex, France aut Kantelip J. Service de Physiopathologie Respiratoire et Cérébrale, Médecine et Biologie du Sport, CHU F-25030, Besançon Cedex, France aut Magnin P. Service de Physiopathologie Respiratoire et Cérébrale, Médecine et Biologie du Sport, CHU F-25030, Besançon Cedex, France aut Gaillard R. Clinique Médicale, Hôpital Cantonal Universitaire, CH-1211, Genéve, Switzerland aut European Journal of Applied Physiology and Occupational Physiology Springer-Verlag 64/4(1992-07-01), 371-376 0301-5548 64:4<371 1992 64 421 https://doi.org/10.1007/BF00636226 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00636226 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Mougin F. Service de Physiopathologie Respiratoire et Cérébrale, Médecine et Biologie du Sport, CHU F-25030, Besançon Cedex, France aut NATIONALLICENCE 700 1- Simon-Rigaud M. Service de Physiopathologie Respiratoire et Cérébrale, Médecine et Biologie du Sport, CHU F-25030, Besançon Cedex, France aut NATIONALLICENCE 700 1- Mougin C. Laboratoire de Virologie, CHU F-25030, Besançon Cedex, France aut NATIONALLICENCE 700 1- Bourdin H. Service de Physiopathologie Respiratoire et Cérébrale, Médecine et Biologie du Sport, CHU F-25030, Besançon Cedex, France aut NATIONALLICENCE 700 1- Jacquier M. Clinique Médicale, Hôpital Cantonal Universitaire, CH-1211, Genéve, Switzerland aut NATIONALLICENCE 700 1- Henriet M. Laboratoire d'Explorations Fonctionnelles Métaboliques et Rénales, CHU F-25 030, Besançon Cedex, France aut NATIONALLICENCE 700 1- Davenne D. Laboratoire d'Etudes et de Recherches sur la Performance Sportive, UFR-STAPS, BP 138, F-21004, Dijon Cedex, France aut NATIONALLICENCE 700 1- Kantelip J. Service de Physiopathologie Respiratoire et Cérébrale, Médecine et Biologie du Sport, CHU F-25030, Besançon Cedex, France aut NATIONALLICENCE 700 1- Magnin P. Service de Physiopathologie Respiratoire et Cérébrale, Médecine et Biologie du Sport, CHU F-25030, Besançon Cedex, France aut NATIONALLICENCE 700 1- Gaillard R. Clinique Médicale, Hôpital Cantonal Universitaire, CH-1211, Genéve, Switzerland aut NATIONALLICENCE 773 0- European Journal of Applied Physiology and Occupational Physiology Springer-Verlag 64/4(1992-07-01), 371-376 0301-5548 64:4<371 1992 64 421 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer