caa a22 4500 469055618 CHVBK 20180323132843.0 cr unu---uuuuu 170328e19920901xx s 000 0 eng 10.1007/BF00625056 doi (NATIONALLICENCE)springer-10.1007/BF00625056 Organ blood flow and cardiac contractility in anaesthetized cats at 5 bar (500 kPa) ambient pressure [Elektronische Daten] [Jan Risberg, Ingvald Tyssebotn] Summary: Previous in vivo and in vitro experiments have demonstrated increased cardiac contractility and increased total myocardial blood flow ( $$\dot Q_{{\text{myocardial}}}$$ ) when rats were exposed to normoxic 5-bar (500 kPa) ambient pressure. In the present study, regional blood flow was measured using the microsphere method on nine anaesthetized cats at surface and normoxic 5-bar (500 kPa) ambient pressure. Left ventricular pressure (LVP) and cadiac contractility, measured as peak left ventricular +dP/dt and −dP/dt were measured in six of the cats. Arterial pressure, heart rate and cardiac output remained unchanged after compression, but total $$\dot Q_{{\text{myocardial}}}$$ increased by 29% (P<0.01) and cerebral blood flow increased by 66% (P<0.05). At the same time +dP/dt and −dP/dt was increased by 83% and 102%, respectively (P<0.01), while LVP was enhanced by 14% (P<0.05). Except for a moderate decrease in partial pressure of oxygen, acid base status in arterial blood remained unchanged. The results indicate that the effects of increased ambient pressure on the heart are general physiological phenomena, which are not only limited to the laboratory rat. Springer-Verlag, 1992 Cats nationallicence Cardiac contractility nationallicence Regional blood flow nationallicence Acid-base equilibrium nationallicence Atmospheric pressure nationallicence Risberg Jan Department of Physiology, University of Bergen, Årstadveien 19, N-5009, Bergen, Norway aut Tyssebotn Ingvald Department of Physiology, University of Bergen, Årstadveien 19, N-5009, Bergen, Norway aut European Journal of Applied Physiology and Occupational Physiology Springer-Verlag 64/5(1992-09-01), 389-394 0301-5548 64:5<389 1992 64 421 https://doi.org/10.1007/BF00625056 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00625056 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Risberg Jan Department of Physiology, University of Bergen, Årstadveien 19, N-5009, Bergen, Norway aut NATIONALLICENCE 700 1- Tyssebotn Ingvald Department of Physiology, University of Bergen, Årstadveien 19, N-5009, Bergen, Norway aut NATIONALLICENCE 773 0- European Journal of Applied Physiology and Occupational Physiology Springer-Verlag 64/5(1992-09-01), 389-394 0301-5548 64:5<389 1992 64 421 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer