caa a22 4500 469055642 CHVBK 20180323132843.0 cr unu---uuuuu 170328e19920901xx s 000 0 eng 10.1007/BF00625065 doi (NATIONALLICENCE)springer-10.1007/BF00625065 Erythropoietic adaptations to endurance training [Elektronische Daten] [Lindsay Weight, Donald Alexander, Terry Elliot, Peter Jacobs] Summary: Erythropoietic adaptations involving the oxygen dissociation curve (ODC) and erythropoietin production have been implicated in the etiology of reduced blood haemoglobin concentrations in sportspersons (known as sports anaemia). A significant increase in the half-saturation pressure indicating a right-shift in the ODC was measured in 34 male [25.8-27.4 mmHg (3.44-3.65 kPa)] and 16 female (25.8-27.7 mmHg (3.44-3.69 kPa)] trained distance runners (P<0.01 for both genders) after completing a standard 42-km marathon. Erythrocyte 2,3-diphosphoglycerate concentrations measured concurrently were unaltered by exercise, although consistently higher in the female compared to the male athletes (P<0.05). The serum erythropoietin (EPO) concentrations of 15 male triathletes (26.3 U · ml−1) were significantly lower than those of 45 male distance runners (31.6 U · ml−1 ;P<0.05). However, the mean serum EPO concentrations of male and female athletes engaged in a variety of sports were not different from those of sedentary control subjects of both sexes (26.5-35.3 U · ml−1). Furthermore, the serum EPO concentrations were unaltered after prolonged strenuous exercise in 20 male marathon runners. These data suggest that the haematological status of these endurance athletes is in fact normal and that the observed shift in the ODC, while providing a physiological advantage during exercise, has no measurable effect on the erythropoietic drive. Springer-Verlag, 1992 Sports anaemia nationallicence Oxygen dissociation curve nationallicence 2,3-Diphosphoglycerate nationallicence Serum erythropoietin nationallicence Weight Lindsay University of Cape Town Leukaemia Centre and the Department of Haematology, University of Cape Town Medical School and Groote Schuur Hospital, Observatory 7925, Cape Town, South Africa aut Alexander Donald University of Cape Town Leukaemia Centre and the Department of Haematology, University of Cape Town Medical School and Groote Schuur Hospital, Observatory 7925, Cape Town, South Africa aut Elliot Terry University of Cape Town Leukaemia Centre and the Department of Haematology, University of Cape Town Medical School and Groote Schuur Hospital, Observatory 7925, Cape Town, South Africa aut Jacobs Peter University of Cape Town Leukaemia Centre and the Department of Haematology, University of Cape Town Medical School and Groote Schuur Hospital, Observatory 7925, Cape Town, South Africa aut European Journal of Applied Physiology and Occupational Physiology Springer-Verlag 64/5(1992-09-01), 444-448 0301-5548 64:5<444 1992 64 421 https://doi.org/10.1007/BF00625065 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00625065 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Weight Lindsay University of Cape Town Leukaemia Centre and the Department of Haematology, University of Cape Town Medical School and Groote Schuur Hospital, Observatory 7925, Cape Town, South Africa aut NATIONALLICENCE 700 1- Alexander Donald University of Cape Town Leukaemia Centre and the Department of Haematology, University of Cape Town Medical School and Groote Schuur Hospital, Observatory 7925, Cape Town, South Africa aut NATIONALLICENCE 700 1- Elliot Terry University of Cape Town Leukaemia Centre and the Department of Haematology, University of Cape Town Medical School and Groote Schuur Hospital, Observatory 7925, Cape Town, South Africa aut NATIONALLICENCE 700 1- Jacobs Peter University of Cape Town Leukaemia Centre and the Department of Haematology, University of Cape Town Medical School and Groote Schuur Hospital, Observatory 7925, Cape Town, South Africa aut NATIONALLICENCE 773 0- European Journal of Applied Physiology and Occupational Physiology Springer-Verlag 64/5(1992-09-01), 444-448 0301-5548 64:5<444 1992 64 421 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer