caa a22 4500 469060069 CHVBK 20180323132854.0 cr unu---uuuuu 170328e19920901xx s 000 0 eng 10.1007/BF01041363 doi (NATIONALLICENCE)springer-10.1007/BF01041363 Szejtli J. CYCLOLAB, Cyclodextrin Research and Development Laboratory, Budapest, Hungary aut The properties and potential uses of cyclodextrin derivatives [Elektronische Daten] [J. Szejtli] The hydroxyl groups can be selectively substituted to control the solubility and the complex forming selectivity of the modified cyclodextrins (CDs). Among the methylated CDs only two well-defined compounds can be taken into consideration: dimethyl- and dimethyl-βCD (DIMEB and TRIMEB). In an aqueous solution of DIMEB the solubility of rather insoluble compounds and drugs like steroids, vitamin D3, lidocaine and hydrocortisone increases. In some cases their stability and bioavailability are also improved. On the other hand, the hydrolysis rate of carmofur, coumarins etc. is retarded by the methylated cyclodextrins with blocked hydroxyl groups. The drug solubilizing capacity of hydroxypropyl-βCD (HPBCD) is in most cases lower than that of DIMEB. The degree of substitution (DS) shows no remarkable effect on the solubilizing properties of HPBCD in the case of indomethacin, Dipiridamole etc., but in the case of Tolnaftate the solubility was enhanced by increasing the DS, other examples are shown. Kluwer Academic Publishers, 1992 cyclodextrin derivatives nationallicence solubility nationallicence drug carrier characteristics nationallicence complex formation nationallicence Journal of inclusion phenomena and molecular recognition in chemistry Kluwer Academic Publishers 14/1(1992-09-01), 25-36 0923-0750 14:1<25 1992 14 10847 https://doi.org/10.1007/BF01041363 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01041363 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Szejtli J. CYCLOLAB, Cyclodextrin Research and Development Laboratory, Budapest, Hungary aut NATIONALLICENCE 773 0- Journal of inclusion phenomena and molecular recognition in chemistry Kluwer Academic Publishers 14/1(1992-09-01), 25-36 0923-0750 14:1<25 1992 14 10847 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer