caa a22 4500 469060190 CHVBK 20180323132854.0 cr unu---uuuuu 170328e19920601xx s 000 0 eng 10.1007/BF01029662 doi (NATIONALLICENCE)springer-10.1007/BF01029662 Inclusion complex formation of acetaminophen by heating and cogrinding with cyclodextrins [Elektronische Daten] [Shan-Yang Lin, Ren-Ing Perng] The effects of heating or grinding processes on the formation of the inclusion complex between acetaminophen andα- orβ-cyclodextrin were investigated. The interaction of excess amounts of acetaminophen with acetaminophen-cyclodextrin systems was also examined. It was found that the process of grinding or freeze-drying did not cause any interaction between acetaminophen andα-cyclodextrin, but heating could result in its complex formation. However, all the processes (heating, freeze-drying and grinding), could improve the inclusion formation of acetaminophen andβ-cyclodextrin. An excess of acetaminophen could easily interact with the inclusion complex of acetaminophen andβ-cyclodextrin to result in an exothermic peak at 160°C in DSC thermograms. Consecutive endothermic and exothermic peaks around 150-160°C appeared in the DSC thermograrns of acetaminophen-β-CD systems, but not in the DSC curves of acetaminophen-α-CD systems. This consecutive transition phenomenon might be due to the fusion of the amorphous state of excessive acetaminophen caused by grinding and the molecular interaction that occurred between an excess of fused acetaminophen and the inclusion complex Kluwer Academic Publishers, 1992 molecular interaction nationallicence inclusion complex nationallicence acetaminophen nationallicence cyclodextrins nationallicence heating nationallicence grinding nationallicence Lin Shan-Yang Biopharmaceutics Laboratory, Department of Medical Research, Veterans General Hospital-Taipei, Taipei, Republic of China aut Perng Ren-Ing Biopharmaceutics Laboratory, Department of Medical Research, Veterans General Hospital-Taipei, Taipei, Republic of China aut Journal of inclusion phenomena and molecular recognition in chemistry Kluwer Academic Publishers 14/2(1992-06-01), 149-156 0923-0750 14:2<149 1992 14 10847 https://doi.org/10.1007/BF01029662 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01029662 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Lin Shan-Yang Biopharmaceutics Laboratory, Department of Medical Research, Veterans General Hospital-Taipei, Taipei, Republic of China aut NATIONALLICENCE 700 1- Perng Ren-Ing Biopharmaceutics Laboratory, Department of Medical Research, Veterans General Hospital-Taipei, Taipei, Republic of China aut NATIONALLICENCE 773 0- Journal of inclusion phenomena and molecular recognition in chemistry Kluwer Academic Publishers 14/2(1992-06-01), 149-156 0923-0750 14:2<149 1992 14 10847 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer