caa a22 4500 469061367 CHVBK 20180323132858.0 cr unu---uuuuu 170328e19920901xx s 000 0 eng 10.1007/BF00302874 doi (NATIONALLICENCE)springer-10.1007/BF00302874 A linkage map of mouse Chromosome 1 using an interspecific cross segregating for the gld autoimmunity mutation [Elektronische Daten] [Mark Watson, Peter D'Eustachio, Beverly Mock, Alfred Steinberg, Herbert Morse III, Rebecca Oakey, Thad Howard, Julie Rochelle, Michael Seldin] An interspecific backross was used to define a high resolution linkage map of mouse Chromosome (Chr) 1 and to analyze the segregation of the generalized lymphoproliferative disease (gld) mutation. Mice homozygous for gld have multiple features of autoimmune disease. Analysis of up to 428 progeny from the backcross [(C3H/HeJ-gld x Mus spretus)F1 x C3H/HeJ-gld] established a map that spans 77.6 cM and includes 56 markers distributed over 34 ordered genetic loci. The gld mutation was mapped to a less than 1 cM segment on distal mouse Chr 1 using 357 gld phenotype-positive backcross mice. A second backcross, between the laboratory strains C57BL/6J and SWR/J, was examined to compare recombination frequency between selected markers on mouse Chr 1. Significant differences in crossover frequency were demonstrated between the interspecific backcross and the inbred laboratory cross for the entire interval studied. Sex difference in meiotic crossover frequency was also significant in the laboratory mouse cross. Two linkage groups known to be conserved between segments of mouse Chr 1 and the long arm of human Chrs 1 and 2 where further defined and a new conserved linkage group was identified that includes markers of distal mouse Chr 1 and human Chr 1, bands q32 to q42. Springer-Verlag New York Inc, 1992 Watson Mark Department of Medicien and Department of Microbiogy, Duke University, 27710, Durham, North Carolina, USA aut D'Eustachio Peter Department of Biochemistry and Kaplan Cancer Center, New York University Medical Center, 10016, New York, New York, USA aut Mock Beverly Laboratory of Genetics, National Cancer Institute, National Institutes of Health, 20892, Bethesda, Maryland, USA aut Steinberg Alfred Cellular Immunology Section, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, 20892, Bethesda, Maryland, USA aut Morse III Herbert Laboratory of Immunopathology, National Institute of Allergy and Infectious Disease, National Institutes of Health, 20892, Bethesda, Maryland, USA aut Oakey Rebecca Department of Medicien and Department of Microbiogy, Duke University, 27710, Durham, North Carolina, USA aut Howard Thad Department of Medicien and Department of Microbiogy, Duke University, 27710, Durham, North Carolina, USA aut Rochelle Julie Department of Medicien and Department of Microbiogy, Duke University, 27710, Durham, North Carolina, USA aut Seldin Michael Department of Medicien and Department of Microbiogy, Duke University, 27710, Durham, North Carolina, USA aut Mammalian Genome Springer-Verlag 2/3(1992-09-01), 158-171 0938-8990 2:3<158 1992 2 335 https://doi.org/10.1007/BF00302874 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00302874 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Watson Mark Department of Medicien and Department of Microbiogy, Duke University, 27710, Durham, North Carolina, USA aut NATIONALLICENCE 700 1- D'Eustachio Peter Department of Biochemistry and Kaplan Cancer Center, New York University Medical Center, 10016, New York, New York, USA aut NATIONALLICENCE 700 1- Mock Beverly Laboratory of Genetics, National Cancer Institute, National Institutes of Health, 20892, Bethesda, Maryland, USA aut NATIONALLICENCE 700 1- Steinberg Alfred Cellular Immunology Section, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, 20892, Bethesda, Maryland, USA aut NATIONALLICENCE 700 1- Morse III Herbert Laboratory of Immunopathology, National Institute of Allergy and Infectious Disease, National Institutes of Health, 20892, Bethesda, Maryland, USA aut NATIONALLICENCE 700 1- Oakey Rebecca Department of Medicien and Department of Microbiogy, Duke University, 27710, Durham, North Carolina, USA aut NATIONALLICENCE 700 1- Howard Thad Department of Medicien and Department of Microbiogy, Duke University, 27710, Durham, North Carolina, USA aut NATIONALLICENCE 700 1- Rochelle Julie Department of Medicien and Department of Microbiogy, Duke University, 27710, Durham, North Carolina, USA aut NATIONALLICENCE 700 1- Seldin Michael Department of Medicien and Department of Microbiogy, Duke University, 27710, Durham, North Carolina, USA aut NATIONALLICENCE 773 0- Mammalian Genome Springer-Verlag 2/3(1992-09-01), 158-171 0938-8990 2:3<158 1992 2 335 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer