caa a22 4500 469061480 CHVBK 20180323132858.0 cr unu---uuuuu 170328e19921201xx s 000 0 eng 10.1007/BF00355431 doi (NATIONALLICENCE)springer-10.1007/BF00355431 Mapping of the mouse ornithine decarboxylase-related sequence family [Elektronische Daten] [Beverly Richards-Smith, Rosemary Elliott] A family of DNA sequences homologous to the mRNA encoding ornithine decarboxylase (ODC) and comprising ∼12 members in the mouse genome has been analyzed genetically. The inheritance of variant DNA restriction fragments detected by ODC cDNA probes on Southern blots of DNA from inbred strain mice was determined in six sets of recombinant inbred (RI) mouse strains. The distributions of these variations among the RI strains were then compared with the RI strain distribution patterns (SDPs) of previously mapped loci. This allowed the identification of nine independent ODC-related loci, of which eight could be localized to specific regions of the mouse genome: Odc-rs1 near Lamb2 on Chromosome (Chr) 1; Odc-rs2 near Psp on Chr 2; Odc-rs5, a complex locus comprising at least 5-7 copies of the ODC sequence, associated with Igk on Chr 6; Odc-rs6 between Abpa and Tam-1 on proximal Chr 7; Odc-rs7 near Hbb on distal Chr 7; Odc-rs12 near Agt and Emv-2 on distal Chr 8; Odc-rs8 associated with the Igh complex on Chr 12; and Odc-rs9 near Otf-3f on Chr 14. The ODC-related sequence family thus comprises a set of genomically dispersed "marker” loci, and alleles for several of these loci can be analyzed simultaneously in DNA from mice or cell lines. DNA from mice of 70 inbred strains has been characterized for alleles at all nine Odc-rs loci. Springer-Verlag New York Inc, 1992 Richards-Smith Beverly Department of Molecular and Cellular Biology, Roswell Park Cancer Institute, 14263, Buffalo, New York, USA aut Elliott Rosemary Department of Molecular and Cellular Biology, Roswell Park Cancer Institute, 14263, Buffalo, New York, USA aut Mammalian Genome Springer-Verlag 2/4(1992-12-01), 215-232 0938-8990 2:4<215 1992 2 335 https://doi.org/10.1007/BF00355431 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00355431 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Richards-Smith Beverly Department of Molecular and Cellular Biology, Roswell Park Cancer Institute, 14263, Buffalo, New York, USA aut NATIONALLICENCE 700 1- Elliott Rosemary Department of Molecular and Cellular Biology, Roswell Park Cancer Institute, 14263, Buffalo, New York, USA aut NATIONALLICENCE 773 0- Mammalian Genome Springer-Verlag 2/4(1992-12-01), 215-232 0938-8990 2:4<215 1992 2 335 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer