caa a22 4500 469061499 CHVBK 20180323132858.0 cr unu---uuuuu 170328e19921201xx s 000 0 eng 10.1007/BF00355436 doi (NATIONALLICENCE)springer-10.1007/BF00355436 The mouse plasminogen locus maps to the recombination breakpoints of the t Lub2and Tt Orlpartial t haplotypes but is not at the t w73locus [Elektronische Daten] [Norbert Schweifer, Denise Barlow] The mouse plasminogen (Plg) locus maps to a region of chromosome (Chr) 17 which is inverted in the t haplotype Chromosomal variant. Here we investigate the genomic organization of the Plg locus in structurally variant forms of Chr 17; wild-type (+), t haplotype (t), and two partial t haplotypes Tt Orland t Lub2which arose by recombination between + and t chromosomes. Our analysis suggests that the t haplotype chromosomal variant contains extra, inverted copies of the Plg locus, and that a single locus is present in the wild-type variant. Changes in the Plg locus in Tt Orland t Lub2suggest that they arose by homologous recombination across elements in the Plg locus having the same orientation in the wild-type and t haplotype chromosomes. One hundred ten kb around the wild-type Plg genomic locus have been cloned and the proximal breakpoint of a deletion in the t Lub2chromosome has been localized to a fragment 30 kb downstream of the Plg gene. The t Lub2deletion has been shown to delete a gene named t w73that affects blastocyst implantation, a process probably requiring proteases such as plasminogen. However, the mapping of Plg relative to the t Lub2deletion and mRNA analysis of plasminogen in t w73heterozygotes suggests that Plg does not lie at the t w73locus. Springer-Verlag New York Inc, 1992 Schweifer Norbert Research Institute of Molecular Pathology, Dr. Bohr-Gasse 7, A-1030, Vienna, Austria aut Barlow Denise Research Institute of Molecular Pathology, Dr. Bohr-Gasse 7, A-1030, Vienna, Austria aut Mammalian Genome Springer-Verlag 2/4(1992-12-01), 260-268 0938-8990 2:4<260 1992 2 335 https://doi.org/10.1007/BF00355436 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00355436 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Schweifer Norbert Research Institute of Molecular Pathology, Dr. Bohr-Gasse 7, A-1030, Vienna, Austria aut NATIONALLICENCE 700 1- Barlow Denise Research Institute of Molecular Pathology, Dr. Bohr-Gasse 7, A-1030, Vienna, Austria aut NATIONALLICENCE 773 0- Mammalian Genome Springer-Verlag 2/4(1992-12-01), 260-268 0938-8990 2:4<260 1992 2 335 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer