caa a22 4500 469061561 CHVBK 20180323132859.0 cr unu---uuuuu 170328e19920601xx s 000 0 eng 10.1007/BF00353857 doi (NATIONALLICENCE)springer-10.1007/BF00353857 The locus Om , responsible for the DDK syndrome, maps close to Sigje on mouse Chromosome 11 [Elektronische Daten] [Patricia Baldacci, Véronique Richoux, Jean-Paul Renard, Jean-Louis Guénet, Charles Babinet] The DDK inbred strain of mouse has a striking particularity: when DDK females are crossed to males of other strains they exhibit a reduced fertility, whereas the reciprocal crosses (non-DDK females x DDK males) are fertile (Wakasugi et al. 1967; Wakasugi 1973). The low fertility results from an early embryonic lethality, the F1 embryos dying near the late morula-early blastocyst stage. Genetic analyses (Wakasugi 1974) and nuclear and cytoplasmic transfers (Renard and Babinet 1986; Babinet et al. 1990; Mann 1986), have shown that the failure of the embryos to develop is due to an incompatibility between a DDK maternally encoded cytoplasmic product and the non-DDK paternal genome. In order to elucidate the genetic determinism of this embryonic lethality, we have analyzed the fertility of male progeny from a backcross BALB/c females x (BALB/c x DDK)F1 males and that of males from a set of recombinant inbred (RI) strains, established from DDK and BALB/c progenitors, when mated with DDK females. Our results indicate that a single locus, Om, is responsible for the DDK syndrome and is located on Chromosome (Chr) 11, very close to the Sigje locus. Springer-Verlag New York Inc, 1992 Baldacci Patricia Unité de Génétique des Mammifères, Institut Pasteur, 25 rue du Docteur Roux, 75724, Paris, Cedex 15, France aut Richoux Véronique Biologie du Développment, INRA, 78350, Jouy en Josas, France aut Renard Jean-Paul Biologie du Développment, INRA, 78350, Jouy en Josas, France aut Guénet Jean-Louis Unité de Génétique des Mammifères, Institut Pasteur, 25 rue du Docteur Roux, 75724, Paris, Cedex 15, France aut Babinet Charles Unité de Génétique des Mammifères, Institut Pasteur, 25 rue du Docteur Roux, 75724, Paris, Cedex 15, France aut Mammalian Genome Springer-Verlag 2/2(1992-06-01), 100-105 0938-8990 2:2<100 1992 2 335 https://doi.org/10.1007/BF00353857 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00353857 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Baldacci Patricia Unité de Génétique des Mammifères, Institut Pasteur, 25 rue du Docteur Roux, 75724, Paris, Cedex 15, France aut NATIONALLICENCE 700 1- Richoux Véronique Biologie du Développment, INRA, 78350, Jouy en Josas, France aut NATIONALLICENCE 700 1- Renard Jean-Paul Biologie du Développment, INRA, 78350, Jouy en Josas, France aut NATIONALLICENCE 700 1- Guénet Jean-Louis Unité de Génétique des Mammifères, Institut Pasteur, 25 rue du Docteur Roux, 75724, Paris, Cedex 15, France aut NATIONALLICENCE 700 1- Babinet Charles Unité de Génétique des Mammifères, Institut Pasteur, 25 rue du Docteur Roux, 75724, Paris, Cedex 15, France aut NATIONALLICENCE 773 0- Mammalian Genome Springer-Verlag 2/2(1992-06-01), 100-105 0938-8990 2:2<100 1992 2 335 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer