caa a22 4500 469061677 CHVBK 20180323132859.0 cr unu---uuuuu 170328e19920101xx s 000 0 eng 10.1007/BF00355837 doi (NATIONALLICENCE)springer-10.1007/BF00355837 Linkage, but not gene order, of homologous loci, including α-L-iduronidase ( Idua ), is conserved in the Huntington disease region of the mouse and human genomes [Elektronische Daten] [Tsutomu Koizumi, Marcy MacDonald, Maja Búcan, John Hopwood, C. Morris, Hamish Scott, James Gusella, Joseph Nadeau] α-L-iduronidase (IDUA), which when deficient causes mucopolysaccharidosis type I, is located near the Huntington disease locus (HD) on human Chromosome (Chr) 4p16.3, approximately 106 base pairs (bp) from the telomere. As part of our continuing efforts to define a detailed comparative map for this chromosomal segment in mice and humans, we have used an interspecific backcross between C57BL/6J and an inbred strain derived from Mus spretus to map Idua, the mouse homolog of IDUA. We also mapped the mouse homolog of D4S115, an anonymous locus approximately 250 kb proximal to IDUA. As expected, both Idua and D4S115h are located on the proximal portion of mouse Chr5 near homologs for other loci on human Chr 4p. Comparison of gene order in mice and humans demonstrates, however, that a chromosomal rearrangement within this conserved synteny has occurred since divergence of lineages leading to mice and humans. Springer-Verlag New York Inc, 1992 Koizumi Tsutomu Institute for Experimental Animals, Kanazawa University School of Medicine, Kanazawa, Japan aut MacDonald Marcy Neurogenetics Laboratory, Massachusetts General Hospital, 02114, Boston, Massachusetts, USA aut Búcan Maja Psychiatry Department, University of Pennsylvania School of Medicine, 19104, Philadelphia, Pennsylvania, USA aut Hopwood John Lysosomal Diseases Research Unit, Department of Chemical Pathology, Adelaide Children's Hospital, 5006, North Adelaide, S.A., Australia aut Morris C. Lysosomal Diseases Research Unit, Department of Chemical Pathology, Adelaide Children's Hospital, 5006, North Adelaide, S.A., Australia aut Scott Hamish Lysosomal Diseases Research Unit, Department of Chemical Pathology, Adelaide Children's Hospital, 5006, North Adelaide, S.A., Australia aut Gusella James Neurogenetics Laboratory, Massachusetts General Hospital, 02114, Boston, Massachusetts, USA aut Nadeau Joseph The Jackson Laboratory, Bar Harbor, 04609, Maine, USA aut Mammalian Genome Springer-Verlag 3/1(1992-01-01), 23-27 0938-8990 3:1<23 1992 3 335 https://doi.org/10.1007/BF00355837 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00355837 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Koizumi Tsutomu Institute for Experimental Animals, Kanazawa University School of Medicine, Kanazawa, Japan aut NATIONALLICENCE 700 1- MacDonald Marcy Neurogenetics Laboratory, Massachusetts General Hospital, 02114, Boston, Massachusetts, USA aut NATIONALLICENCE 700 1- Búcan Maja Psychiatry Department, University of Pennsylvania School of Medicine, 19104, Philadelphia, Pennsylvania, USA aut NATIONALLICENCE 700 1- Hopwood John Lysosomal Diseases Research Unit, Department of Chemical Pathology, Adelaide Children's Hospital, 5006, North Adelaide, S.A., Australia aut NATIONALLICENCE 700 1- Morris C. Lysosomal Diseases Research Unit, Department of Chemical Pathology, Adelaide Children's Hospital, 5006, North Adelaide, S.A., Australia aut NATIONALLICENCE 700 1- Scott Hamish Lysosomal Diseases Research Unit, Department of Chemical Pathology, Adelaide Children's Hospital, 5006, North Adelaide, S.A., Australia aut NATIONALLICENCE 700 1- Gusella James Neurogenetics Laboratory, Massachusetts General Hospital, 02114, Boston, Massachusetts, USA aut NATIONALLICENCE 700 1- Nadeau Joseph The Jackson Laboratory, Bar Harbor, 04609, Maine, USA aut NATIONALLICENCE 773 0- Mammalian Genome Springer-Verlag 3/1(1992-01-01), 23-27 0938-8990 3:1<23 1992 3 335 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer