caa a22 4500 469061685 CHVBK 20180323132859.0 cr unu---uuuuu 170328e19920101xx s 000 0 eng 10.1007/BF00355838 doi (NATIONALLICENCE)springer-10.1007/BF00355838 A mouse Y Chromosome pseudogene is related to human ubiquitin activating enzyme E1 [Elektronische Daten] [Priscilla Tucker, Kimberly Phillips, Barbara Lundrigan] A 2041 bp DNA fragment isolated from the Sxr (sex reversed) region of the mouse Y Chromosome (Chr) was sequenced and characterized. The sequence, pY8/b, contains four exons that are highly similar to 525 contiguous bases from the cDNA of human ubiquitin activating enzyme El. Two of the exons contain stop codons, indicating that pY8/b is not part of a functional gene. Sequences related to pY8/b were amplified from the Y Chr of the inbred mouse strain, C57BL/6J. These sequences may be portions of the recently discovered functional equivalent of pY8/b. Despite a high degree of similarity with the human El gene, the functional equivalent of pY8/b is not the mouse El gene, because unlike El, the functional equivalent of pY8/b is expressed in a tissue-specific manner. These data are discussed with respect to theory on the evolution of the mammalian Y Chr, and in particular, to the prediction that functional genes on the Y Chr have a male-specific function. Springer-Verlag New York Inc, 1992 Tucker Priscilla The Museum of Zoology, University of Michigan, 48 109, Ann Arbor, Michigan, USA aut Phillips Kimberly The Museum of Zoology, University of Michigan, 48 109, Ann Arbor, Michigan, USA aut Lundrigan Barbara The Museum of Zoology, University of Michigan, 48 109, Ann Arbor, Michigan, USA aut Mammalian Genome Springer-Verlag 3/1(1992-01-01), 28-35 0938-8990 3:1<28 1992 3 335 https://doi.org/10.1007/BF00355838 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00355838 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Tucker Priscilla The Museum of Zoology, University of Michigan, 48 109, Ann Arbor, Michigan, USA aut NATIONALLICENCE 700 1- Phillips Kimberly The Museum of Zoology, University of Michigan, 48 109, Ann Arbor, Michigan, USA aut NATIONALLICENCE 700 1- Lundrigan Barbara The Museum of Zoology, University of Michigan, 48 109, Ann Arbor, Michigan, USA aut NATIONALLICENCE 773 0- Mammalian Genome Springer-Verlag 3/1(1992-01-01), 28-35 0938-8990 3:1<28 1992 3 335 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer