caa a22 4500 469061758 CHVBK 20180323132859.0 cr unu---uuuuu 170328e19921201xx s 000 0 eng 10.1007/BF00444364 doi (NATIONALLICENCE)springer-10.1007/BF00444364 Fine-structure mapping of the complex locus Odc-rs5 relative to Igk and distal loci [Elektronische Daten] [Beverly Richards-Smith, Rosemary Elliott] Odc-rs5 was previously identified as a complex locus closely linked to the Igk complex on mouse Chromosome (Chr) 6 and comprising at least five copies of a sequence related to the mRNA encoding ornithine decarboxylase (ODC) in the genomes of mice of some inbred strains and at least seven copies in others (Richards-Smith and Elliott, Mammalian Genome 2: 215, 1992). In the present study, Odc-rs5 was shown to be composed of at least seven copies of the ODC sequence in both the Odc-rs5 a and Odc-rs5 b haplotypes. Based upon the distribution of DNA restriction fragments (RFs) that had previously been associated with Odc-rs5 a or Odc-rs5 b among 42 mice of inbred laboratory strains having various haplotypes at Igk and in mice of two congenic strains [B6.PL-Ly-2 a, Ly-3 a(75NS)/Cy and B6.PL-Ly-2 a, Ly-3 a(85NS)/Cy] and a backcross-derived stock (NAK) known to be recombinant within Igk, a fine structure map of Odc-rs5 was deduced relative to Igk and more distal loci. Odc-rs5-derived RFs were located to three distinct regions within and/or distal to Igk and to a fourth site between (Ly-3, Ly-2) and Raf-1. Additionally, DNAs from 19 mice of inbred strains and random-bred stocks derived from wild progenitors trapped at various locations were analyzed and found to exhibit an unexpected variety of combinations of RFs associated with the two Odc-rs5 haplotypes most frequently observed among inbred laboratory strains of mice. Springer-Verlag New York Inc, 1992 Richards-Smith Beverly Department of Molecular and Cellular Biology, Roswell Park Cancer Institute, Elm and Carlton Streets, 14263, Buffalo, New York, USA aut Elliott Rosemary Department of Molecular and Cellular Biology, Roswell Park Cancer Institute, Elm and Carlton Streets, 14263, Buffalo, New York, USA aut Mammalian Genome Springer-Verlag 3/12(1992-12-01), 689-699 0938-8990 3:12<689 1992 3 335 https://doi.org/10.1007/BF00444364 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00444364 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Richards-Smith Beverly Department of Molecular and Cellular Biology, Roswell Park Cancer Institute, Elm and Carlton Streets, 14263, Buffalo, New York, USA aut NATIONALLICENCE 700 1- Elliott Rosemary Department of Molecular and Cellular Biology, Roswell Park Cancer Institute, Elm and Carlton Streets, 14263, Buffalo, New York, USA aut NATIONALLICENCE 773 0- Mammalian Genome Springer-Verlag 3/12(1992-12-01), 689-699 0938-8990 3:12<689 1992 3 335 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer