caa a22 4500 469061790 CHVBK 20180323132859.0 cr unu---uuuuu 170328e19921201xx s 000 0 eng 10.1007/BF00444362 doi (NATIONALLICENCE)springer-10.1007/BF00444362 The murine leukemia inhibition factor gene ( Lif ) is located on proximal Chromosome 11, not Chromosome 13 [Elektronische Daten] [Drell Bottorff, James Stone] Lif, the murine gene encoding leukemia inhibition factor (LIF), has been previously localized to proximal Chromosome (Chr) 11. Hilda, the murine gene encoding "human interleukin in DA cells” (HILDA) has been localized to Chr 13. Since these two growth factors are identical, the proposal for two different structural loci is intriguing. To address this issue, blot hybridization methods have been used to establish the position of the structural gene sequence unambiguously. DNAs from somatic cell hybrids, recombinant inbred mice, and backcross mice have been probed with a sequence that encodes LIF/HILDA. The results support the assignment of this sequence to proximal Chr 11. These studies also establish a synteny group, including Lif and Tcn-2, the structural gene for transcobalamin 2, that is conserved between man and mouse. Springer-Verlag New York Inc, 1992 Bottorff Drell Department of Biochemistry, University of Alberta, T6G 2H7, Edmonton, Alberta, Canada aut Stone James Department of Biochemistry, University of Alberta, T6G 2H7, Edmonton, Alberta, Canada aut Mammalian Genome Springer-Verlag 3/12(1992-12-01), 681-684 0938-8990 3:12<681 1992 3 335 https://doi.org/10.1007/BF00444362 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00444362 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Bottorff Drell Department of Biochemistry, University of Alberta, T6G 2H7, Edmonton, Alberta, Canada aut NATIONALLICENCE 700 1- Stone James Department of Biochemistry, University of Alberta, T6G 2H7, Edmonton, Alberta, Canada aut NATIONALLICENCE 773 0- Mammalian Genome Springer-Verlag 3/12(1992-12-01), 681-684 0938-8990 3:12<681 1992 3 335 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer