caa a22 4500 469061839 CHVBK 20180323132859.0 cr unu---uuuuu 170328e19920301xx s 000 0 eng 10.1007/BF00352461 doi (NATIONALLICENCE)springer-10.1007/BF00352461 Organization and chromosomal locations of Rap1a/Krev sequences in the mouse [Elektronische Daten] [Nancy Dower, Michael Seldin, Sherri Pugh, James Stone] The human RAP1A gene encodes a protein that apparently can antagonize the function of oncogenic ras genes in gene transfer experiments, but its normal function is unknown. To understand the function of this gene, we have undertaken a study of the mouse homolog, Rap1a. The complete coding sequence of a mouse Rap1a cDNA has been determined, and genomic clones representing three distinct Rap1a species were recovered. We find that Rap1a is located on distal mouse Chromosome (Chr) 3 near Nras, Ampd-1, Tshb, Ngfb, and Atp1a1. Two related sequences (Rap1a-rs1 and Rap1a-rs2) were also characterized. Rap1a-rs1, which was not localized, has a sequence very similar to the Rap1a cDNA, suggesting that it has been recently acquired by the mouse genome. Rap1a-rs2 is more distantly related to the gene sequence and is located on Chr 2 near Actc-1. Springer-Verlag New York Inc, 1992 Dower Nancy Department of Paediatrics, University of Alberta, Edmonton, Alberta, Canada aut Seldin Michael Department of Medicine, Duke University Medical Center, Box 3380, 27710, Durham, North Carolina, USA aut Pugh Sherri Neurogenetics Laboratory, Massachusetts General Hospital, 02215, Boston, Massachusetts, USA aut Stone James Department of Biochemistry, University of Alberta, Edmonton, Alberta, Canada aut Mammalian Genome Springer-Verlag 3/3(1992-03-01), 162-167 0938-8990 3:3<162 1992 3 335 https://doi.org/10.1007/BF00352461 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00352461 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Dower Nancy Department of Paediatrics, University of Alberta, Edmonton, Alberta, Canada aut NATIONALLICENCE 700 1- Seldin Michael Department of Medicine, Duke University Medical Center, Box 3380, 27710, Durham, North Carolina, USA aut NATIONALLICENCE 700 1- Pugh Sherri Neurogenetics Laboratory, Massachusetts General Hospital, 02215, Boston, Massachusetts, USA aut NATIONALLICENCE 700 1- Stone James Department of Biochemistry, University of Alberta, Edmonton, Alberta, Canada aut NATIONALLICENCE 773 0- Mammalian Genome Springer-Verlag 3/3(1992-03-01), 162-167 0938-8990 3:3<162 1992 3 335 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer