caa a22 4500 469061855 CHVBK 20180323132859.0 cr unu---uuuuu 170328e19920301xx s 000 0 eng 10.1007/BF00352458 doi (NATIONALLICENCE)springer-10.1007/BF00352458 Framework multipoint map of the long arm of human Chromosome 4 and telomeric localization of the gene for FSHD [Elektronische Daten] [Barbara Weiffenbach, Rebecca Bagley, Kathleen Falls, JoAnn Dubois, Craig Hyser, Diane Storvick, Paul Schultz, Jerry Mendell, Eric Millner, Stephen Jacobsen, Robert Griggs] Mapping the long arm of Chromosome (Chr) 4 has assumed medical relevance with the establishment of linkage of facioscapulohumeral muscular dystrophy (FSHD) to distal 4q markers. We have constructed a multipoint linkage map using DNA markers that map to the long arm of Chr 4. Segregation data were collected for 17 DNA markers on the multigenerational CEPH mapping families, and data for one marker were taken from the published CEPH database. Genotypic information for six of these markers was also collected from a set of 24 families that exhibited inheritance of FSHD. Multipoint analyses allowed us to construct a map of 12 loci, connecting two previously separate linkage groups. Significant sexspecific differences in recombination were found for some genetic intervals. Four loci from the distal region of this map showed linkage with FSHD. A map using these terminal markers gave the strongest support for FSHD in the most distal position over all other possible positions. Springer-Verlag New York Inc, 1992 Weiffenbach Barbara Collaborative Research, Inc., 1365 Main Street, 02154, Waltham, Massachusetts, USA aut Bagley Rebecca Collaborative Research, Inc., 1365 Main Street, 02154, Waltham, Massachusetts, USA aut Falls Kathleen Collaborative Research, Inc., 1365 Main Street, 02154, Waltham, Massachusetts, USA aut Dubois JoAnn Collaborative Research, Inc., 1365 Main Street, 02154, Waltham, Massachusetts, USA aut Hyser Craig Department of Neurology, University of Rochester, 14642, Rochester, New York, USA aut Storvick Diane Department of Neurology, University of Rochester, 14642, Rochester, New York, USA aut Schultz Paul Department of Neurosciences, University of California, San Diego, 92093, La Jolla, California, USA aut Mendell Jerry Department of Neurology, Ohio State University, 43210, Columbus, Ohio, USA aut Millner Eric Virginia Mason Research Center, 98101, Seattle, Washington, USA aut Jacobsen Stephen Department of Pediatrics, University of California, San Diego, 92093, La Jolla, California, USA aut Griggs Robert Department of Neurology, University of Rochester, 14642, Rochester, New York, USA aut Mammalian Genome Springer-Verlag 3/3(1992-03-01), 143-150 0938-8990 3:3<143 1992 3 335 https://doi.org/10.1007/BF00352458 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00352458 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Weiffenbach Barbara Collaborative Research, Inc., 1365 Main Street, 02154, Waltham, Massachusetts, USA aut NATIONALLICENCE 700 1- Bagley Rebecca Collaborative Research, Inc., 1365 Main Street, 02154, Waltham, Massachusetts, USA aut NATIONALLICENCE 700 1- Falls Kathleen Collaborative Research, Inc., 1365 Main Street, 02154, Waltham, Massachusetts, USA aut NATIONALLICENCE 700 1- Dubois JoAnn Collaborative Research, Inc., 1365 Main Street, 02154, Waltham, Massachusetts, USA aut NATIONALLICENCE 700 1- Hyser Craig Department of Neurology, University of Rochester, 14642, Rochester, New York, USA aut NATIONALLICENCE 700 1- Storvick Diane Department of Neurology, University of Rochester, 14642, Rochester, New York, USA aut NATIONALLICENCE 700 1- Schultz Paul Department of Neurosciences, University of California, San Diego, 92093, La Jolla, California, USA aut NATIONALLICENCE 700 1- Mendell Jerry Department of Neurology, Ohio State University, 43210, Columbus, Ohio, USA aut NATIONALLICENCE 700 1- Millner Eric Virginia Mason Research Center, 98101, Seattle, Washington, USA aut NATIONALLICENCE 700 1- Jacobsen Stephen Department of Pediatrics, University of California, San Diego, 92093, La Jolla, California, USA aut NATIONALLICENCE 700 1- Griggs Robert Department of Neurology, University of Rochester, 14642, Rochester, New York, USA aut NATIONALLICENCE 773 0- Mammalian Genome Springer-Verlag 3/3(1992-03-01), 143-150 0938-8990 3:3<143 1992 3 335 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer