caa a22 4500 469062274 CHVBK 20180323132901.0 cr unu---uuuuu 170328e19920401xx s 000 0 eng 10.1007/BF00355720 doi (NATIONALLICENCE)springer-10.1007/BF00355720 Close linkage of retinoic acid receptor genes with homeobox- and keratin-encoding genes on paralogous segments of mouse Chromosomes 11 and 15 [Elektronische Daten] [Joseph Nadeau, John Compton, Vincent Giguère, Janet Rossant, Sue Varmuza] Retinoic acid is essential for normal development and growth of structures such as head and limbs, and it can act as morphogen or teratogen. Retinoic acid induces expression of genes such as the homeobox genes and keratin type I and type II genes. Retinoic acid receptors are nuclear transcription factors that play a key role in retinoid physiology. As part of the characterization of retinoic acid receptor gene family, linkage of genes encoding the three receptors was determined by using interspecific backcross and recombinant inbred strain analysis of restriction fragment variants. Retinoic acid receptor α is located on mouse Chromosome (Chr) 11 near the homeobox-2 complex and the keratin type I gene complex, whereas retinoic acid receptor γ is on mouse Chr 15 near the homeobox-3 complex and the keratin type II complex. Close genetic proximity of these functionally related genes may be significant. We confirmed assignment of retinoic acid receptor β to the centromeric portion of Chr 14. These linkage assignments provide further evidence for duplicated segments in the mouse genome. Springer-Verlag New York Inc., 1992 Nadeau Joseph The Jackson Laboratory, 04609, Bar Harbor, Maine, USA aut Compton John The Jackson Laboratory, 04609, Bar Harbor, Maine, USA aut Giguère Vincent Division of Endocrinology, Research Institute, Hospital for Sick Children, 555 University Avenue, M5G 1X8, Toronto, Canada aut Rossant Janet Division of Molecular and Developmental Biology, Mt. Sinai Hospital Research Institute, M5G 1X5, Toronto, Canada aut Varmuza Sue Department of Zoology, University of Toronto, M5S 1A1, Toronto, Canada aut Mammalian Genome Springer-Verlag 3/4(1992-04-01), 202-208 0938-8990 3:4<202 1992 3 335 https://doi.org/10.1007/BF00355720 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00355720 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Nadeau Joseph The Jackson Laboratory, 04609, Bar Harbor, Maine, USA aut NATIONALLICENCE 700 1- Compton John The Jackson Laboratory, 04609, Bar Harbor, Maine, USA aut NATIONALLICENCE 700 1- Giguère Vincent Division of Endocrinology, Research Institute, Hospital for Sick Children, 555 University Avenue, M5G 1X8, Toronto, Canada aut NATIONALLICENCE 700 1- Rossant Janet Division of Molecular and Developmental Biology, Mt. Sinai Hospital Research Institute, M5G 1X5, Toronto, Canada aut NATIONALLICENCE 700 1- Varmuza Sue Department of Zoology, University of Toronto, M5S 1A1, Toronto, Canada aut NATIONALLICENCE 773 0- Mammalian Genome Springer-Verlag 3/4(1992-04-01), 202-208 0938-8990 3:4<202 1992 3 335 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer