caa a22 4500 469062290 CHVBK 20180323132901.0 cr unu---uuuuu 170328e19920401xx s 000 0 eng 10.1007/BF00355718 doi (NATIONALLICENCE)springer-10.1007/BF00355718 PCR-analyzed microsatellites of the mouse genome—additional polymorphisms among ten inbred mouse strains [Elektronische Daten] [George Fowlis, Simon Adelman, Andrew Knight, Elizabeth Simpson] Eighty sequences from the mouse genome database containing microsatellites (simple sequence repeats) have been analyzed for size variation among ten different inbred strains of mice; 62/80 (77.5%) showed polymorphism of at least three alleles. We have been able to detect all the polymorphims by agarose gel electrophoresis, often running the gels for up to 3 h. Between individual pairs of mouse strains to be used in chromosomal mapping studies in our laboratory, 35-60% polymorphism occurred. There are potentially enough microsatellites within the mouse and human genome to have a marker at every 1-cM distance. This simple approach will, therefore, continue to be useful in genome mapping studies, leading eventually to high-resolution maps of both the mouse and human genomes; this should allow for physical mapping and cloning of specific genes. Springer-Verlag New York Inc., 1992 Fowlis George Transplantation Biology Section, MRC Clinical Research Centre, Watford Road, HA1 3UJ, Harrow, Middlesex, UK aut Adelman Simon Transplantation Biology Section, MRC Clinical Research Centre, Watford Road, HA1 3UJ, Harrow, Middlesex, UK aut Knight Andrew Transplantation Biology Section, MRC Clinical Research Centre, Watford Road, HA1 3UJ, Harrow, Middlesex, UK aut Simpson Elizabeth Transplantation Biology Section, MRC Clinical Research Centre, Watford Road, HA1 3UJ, Harrow, Middlesex, UK aut Mammalian Genome Springer-Verlag 3/4(1992-04-01), 192-196 0938-8990 3:4<192 1992 3 335 https://doi.org/10.1007/BF00355718 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00355718 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Fowlis George Transplantation Biology Section, MRC Clinical Research Centre, Watford Road, HA1 3UJ, Harrow, Middlesex, UK aut NATIONALLICENCE 700 1- Adelman Simon Transplantation Biology Section, MRC Clinical Research Centre, Watford Road, HA1 3UJ, Harrow, Middlesex, UK aut NATIONALLICENCE 700 1- Knight Andrew Transplantation Biology Section, MRC Clinical Research Centre, Watford Road, HA1 3UJ, Harrow, Middlesex, UK aut NATIONALLICENCE 700 1- Simpson Elizabeth Transplantation Biology Section, MRC Clinical Research Centre, Watford Road, HA1 3UJ, Harrow, Middlesex, UK aut NATIONALLICENCE 773 0- Mammalian Genome Springer-Verlag 3/4(1992-04-01), 192-196 0938-8990 3:4<192 1992 3 335 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer