caa a22 4500 469062738 CHVBK 20180323132902.0 cr unu---uuuuu 170328e19921101xx s 000 0 eng 10.1007/BF00352481 doi (NATIONALLICENCE)springer-10.1007/BF00352481 A detailed linkage map of subtelomeric murine Chromosome 12 region including the situs inversus mutation locus IV [Elektronische Daten] [Anne de Meeus, Sandrine Alonso, Jacques Demaille, Patrice Bouvagnet] A mouse model is an invaluable tool to tackle genesis of human congenital diseases that have so far eluded human studies. Homozygote for the iv mutation, the murine Si/Col strain presents a left-right lateralization defect of thoracic and abdominal organs and heart defects very similar to human ones. This iv mutation has been mapped to the region between the Aat and Igh-C loci, suggesting the presence of an equivalent human gene in the human syntenic 14q3 region. A precise linkage map of the region is, there-fore, of great interest since it will contribute to the genetic approach of the iv gene. Analysis of 242 backcross progeny from Mus musculus (MAI) or spretus strains of mice and SI/Col mice has allowed mapping of the iv gene to a linkage group of eight markers. It includes four genes: Aat (α1-antitrypsin), Ckb (creatine kinase, brain form), Crip (cysteine-rich intestinal protein), and Igh-C (immunoglobulin heavy chain constant region complex); three murine microsatellites: D12Mit6, D12Mit7, and D12Mit8; and one new marker, D12Mtpl, defined by a minisatellite human probe, pYNZ2. After analysis of the data by the LINKAGE program, the following multilocus map has been constructed: centromere-D12Mit6-6.9 cM-D12Mit7-1.7 cM-D12Mtp1-2.6 cM-Aat-5.0 cM-(Ckb, Igh-C)-0.4 cM-D12Mit8-0.4 cM-Crip-11.2 cM-iv-telomere. This map differs from the previous map in placing iv locus telomeric to Igh-C. D12Mit6 and D12Mit7 are now precisely mapped centromeric to the locus Aat. In addition, a new locus D12Mtp1 is located between Aat and D12Mit7. Springer-Verlag New York Inc, 1992 de Meeus Anne Centre de Recherche de Biochimie Macromoléculaire, CNRS UPR-9008 et INSERM U249, 1919 route de Mende, 34033, Montpellier, France aut Alonso Sandrine Centre de Recherche de Biochimie Macromoléculaire, CNRS UPR-9008 et INSERM U249, 1919 route de Mende, 34033, Montpellier, France aut Demaille Jacques Centre de Recherche de Biochimie Macromoléculaire, CNRS UPR-9008 et INSERM U249, 1919 route de Mende, 34033, Montpellier, France aut Bouvagnet Patrice Centre de Recherche de Biochimie Macromoléculaire, CNRS UPR-9008 et INSERM U249, 1919 route de Mende, 34033, Montpellier, France aut Mammalian Genome Springer-Verlag 3/11(1992-11-01), 637-643 0938-8990 3:11<637 1992 3 335 https://doi.org/10.1007/BF00352481 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00352481 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- de Meeus Anne Centre de Recherche de Biochimie Macromoléculaire, CNRS UPR-9008 et INSERM U249, 1919 route de Mende, 34033, Montpellier, France aut NATIONALLICENCE 700 1- Alonso Sandrine Centre de Recherche de Biochimie Macromoléculaire, CNRS UPR-9008 et INSERM U249, 1919 route de Mende, 34033, Montpellier, France aut NATIONALLICENCE 700 1- Demaille Jacques Centre de Recherche de Biochimie Macromoléculaire, CNRS UPR-9008 et INSERM U249, 1919 route de Mende, 34033, Montpellier, France aut NATIONALLICENCE 700 1- Bouvagnet Patrice Centre de Recherche de Biochimie Macromoléculaire, CNRS UPR-9008 et INSERM U249, 1919 route de Mende, 34033, Montpellier, France aut NATIONALLICENCE 773 0- Mammalian Genome Springer-Verlag 3/11(1992-11-01), 637-643 0938-8990 3:11<637 1992 3 335 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer