caa a22 4500 469062762 CHVBK 20180323132902.0 cr unu---uuuuu 170328e19921101xx s 000 0 eng 10.1007/BF00352479 doi (NATIONALLICENCE)springer-10.1007/BF00352479 Genetic mapping of the murine gene and 14 related sequences encoding chromosomal protein HMG-14 [Elektronische Daten] [Kenneth Johnson, Sue Cook, Michael Bustin, Muriel Davisson] The high-mobility-group chromosomal protein HMG-14 preferentially binds to nucleosomal core particles of mammalian chromatin and may modulate the chromatin configuration of transcriptionally active genes. The human gene for HMG-14 has been localized to the Down syndrome region of Chromosome (Chr) 21 and may be involved in the etiology of this syndrome. Here we show, by means of genetic linkage analysis of interspecific and intersubspecific backcross mice, that the murine functional gene, Hmg 14, is located on the distal end of mouse Chr 16, a region known to have conserved synteny with human Chr 21. In addition to the functional gene for HMG-14, both human and mouse genomes contain many related sequences that are probably processed pseudogenes. Here we map the locations of 14 Hmg 14-related sequences in two mouse genomes. The 14 mapped loci are widely dispersed on ten chromosomes (Chrs 3, 5, 7, 9, 11, 12, 16, 17, 19, and X) and can be detected efficiently with a single cDNA probe. Thus, the Hmg14 multigene family is well suited to serve as genetic markers for other linkage studies in mice. Springer-Verlag New York Inc, 1992 Johnson Kenneth The Jackson Laboratory, 600 Main Street, 04609, Bar Harbor, Maine, USA aut Cook Sue The Jackson Laboratory, 600 Main Street, 04609, Bar Harbor, Maine, USA aut Bustin Michael Laboratory of Molecular Carcinogenesis, National Cancer Institute, National Institutes of Health, 20892, Bethesda, Maryland, USA aut Davisson Muriel The Jackson Laboratory, 600 Main Street, 04609, Bar Harbor, Maine, USA aut Mammalian Genome Springer-Verlag 3/11(1992-11-01), 625-632 0938-8990 3:11<625 1992 3 335 https://doi.org/10.1007/BF00352479 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00352479 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Johnson Kenneth The Jackson Laboratory, 600 Main Street, 04609, Bar Harbor, Maine, USA aut NATIONALLICENCE 700 1- Cook Sue The Jackson Laboratory, 600 Main Street, 04609, Bar Harbor, Maine, USA aut NATIONALLICENCE 700 1- Bustin Michael Laboratory of Molecular Carcinogenesis, National Cancer Institute, National Institutes of Health, 20892, Bethesda, Maryland, USA aut NATIONALLICENCE 700 1- Davisson Muriel The Jackson Laboratory, 600 Main Street, 04609, Bar Harbor, Maine, USA aut NATIONALLICENCE 773 0- Mammalian Genome Springer-Verlag 3/11(1992-11-01), 625-632 0938-8990 3:11<625 1992 3 335 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer