caa a22 4500 469063963 CHVBK 20180323132902.0 cr unu---uuuuu 170328e19920301xx s 000 0 eng 10.1007/BF02914369 doi (NATIONALLICENCE)springer-10.1007/BF02914369 Immune deficiencies in chronic lymphocytic leukemia and multiple myeloma [Elektronische Daten] [Alan Winkelstein, P. Jordan] Research related to the etiology and mechanisms of immunodeficiency in B-cell neoplasms has helped to identify prophylactic and therapeutic measures to manage infections, which remain the leading cause of death despite antimicrobial therapy. In both CLL and multiple myeloma, defective antibody formation is a key risk factor for developing infection. Preliminary data indicate that IVIG replacement therapy is an effective and safe means to improve the antibody profile and reduce the incidence of infection in some patients with either of these B-cell malignancies. Replacement therapy alone is not sufficient. However, in a subset of affected patients who experience recurrent infections, IVIGs may be beneficial as adjunctive therapy when used in conjunction with chemotherapy for the underlying malignancy and antibiotic therapy for acute infections. Further studies are needed to better define their role and to identify those patients who are most likely to benefit from IVIGs. The Humana Press Inc, 1992 Winkelstein Alan Montefiore University Hospital, 3459 Fifth Avenue, 15213, Pittsburgh, PA aut Jordan P. PharmD, Pomona, NY aut Clinical Reviews in Allergy Humana Press 10/1-2(1992-03-01), 39-58 0731-8235 10:1-2<39 1992 10 12016 https://doi.org/10.1007/BF02914369 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02914369 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Winkelstein Alan Montefiore University Hospital, 3459 Fifth Avenue, 15213, Pittsburgh, PA aut NATIONALLICENCE 700 1- Jordan P. PharmD, Pomona, NY aut NATIONALLICENCE 773 0- Clinical Reviews in Allergy Humana Press 10/1-2(1992-03-01), 39-58 0731-8235 10:1-2<39 1992 10 12016 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer