caa a22 4500 469064048 CHVBK 20180323132902.0 cr unu---uuuuu 170328e19920301xx s 000 0 eng 10.1007/BF02914367 doi (NATIONALLICENCE)springer-10.1007/BF02914367 Current status of intravenous immunoglobuiin in preventing or treating neonatal bacterial infections [Elektronische Daten] [Leonard Weisman, David Cruess, Gerald Fischer] Although current studies suggest that IVIG is safe, larger controlled trials will soon be published and will be important to confirm this observation. In addition, the current studies do not establish the efficacy of IVIG for either treating or preventing neonatal bacterial infections. Some studies with small numbers of babies suggest benefit of IVIG therapy and prophylaxis; however, the studies reviewed do not, individually or combined, prove efficacy. Clinicians and investigators must not confuse studies that prevent infection with those that treat infection, since different therapeutic regimens may be necessary. Many questions remain concerning IVIG therapy, such as: Is IVIG efficacious in preventing or treating neonatal sepsis? What is the appropriate immunoglobulin dosage? How variable is the pathogen-specific antibody activity of standard IVIG products? For effectively determining the appropriate use of IVIG in neonates, well-designed and carefully controlled trials are needed to address these issues, using sufficiently large numbers of babies to arrive at valid scientific conclusions. Although many questions will be answered with the trials currently in progress, we must continue to base further recommendations for immunoglobulin therapy on solid scientific data. The Humana Press Inc, 1992 Weisman Leonard Department of Pediatrics, Uniformed Services University, 20814, Bethesda, MD aut Cruess David Department of Preventive Medicine and Biometrics, Uniformed Services University, 20814, Bethesda, MD aut Fischer Gerald Department of Pediatrics, Uniformed Services University, 20814, Bethesda, MD aut Clinical Reviews in Allergy Humana Press 10/1-2(1992-03-01), 13-28 0731-8235 10:1-2<13 1992 10 12016 https://doi.org/10.1007/BF02914367 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02914367 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Weisman Leonard Department of Pediatrics, Uniformed Services University, 20814, Bethesda, MD aut NATIONALLICENCE 700 1- Cruess David Department of Preventive Medicine and Biometrics, Uniformed Services University, 20814, Bethesda, MD aut NATIONALLICENCE 700 1- Fischer Gerald Department of Pediatrics, Uniformed Services University, 20814, Bethesda, MD aut NATIONALLICENCE 773 0- Clinical Reviews in Allergy Humana Press 10/1-2(1992-03-01), 13-28 0731-8235 10:1-2<13 1992 10 12016 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer