caa a22 4500 469064072 CHVBK 20180323132903.0 cr unu---uuuuu 170328e19920301xx s 000 0 eng 10.1007/BF02914370 doi (NATIONALLICENCE)springer-10.1007/BF02914370 Nugent Diane Division of Hematology-Oncology, Department of Pediatrics, University of Wisconsin, 1300 University Ave MSC 3590, 53706, Madison, Wl aut IVIG in the treatment of children with acute and chronic ldiopathic thrombocytopenic purpura and the autoimmune cytopenias [Elektronische Daten] [Diane Nugent] IVIG has been shown to be useful in the treatment of acute and chronic ITP, immune neutropenia, and in some cases of AIHA. The mechanism of action of IVIG is owing to a number of factors, which include Fc blockade, immune modulation of T- and B-cell number and function, alterations in NK activity, and direct effects on autoantibody binding and production via the antiidiotypic antibody network. Current research efforts are directed toward elucidation of these modalities and determination of their relative importance in treating patients with immune-mediated cytopenias. The Humana Press Inc, 1992 Clinical Reviews in Allergy Humana Press 10/1-2(1992-03-01), 59-71 0731-8235 10:1-2<59 1992 10 12016 https://doi.org/10.1007/BF02914370 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02914370 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Nugent Diane Division of Hematology-Oncology, Department of Pediatrics, University of Wisconsin, 1300 University Ave MSC 3590, 53706, Madison, Wl aut NATIONALLICENCE 773 0- Clinical Reviews in Allergy Humana Press 10/1-2(1992-03-01), 59-71 0731-8235 10:1-2<59 1992 10 12016 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer