caa a22 4500 469073454 CHVBK 20180323132928.0 cr unu---uuuuu 170328e19920101xx s 000 0 eng 10.1007/BF01741047 doi (NATIONALLICENCE)springer-10.1007/BF01741047 Tumor-immunotherapy with the use of tumor-antigen-pulsed antigen-presenting cells [Elektronische Daten] [Jian-ping Zou, Jun Shimizu, Kazuhiro Ikegame, Hidekazu Takiuchi, Hiromi Fujiwara, Toshiyuki Hamaoka] Summary: Our previous study demonstrated that the administration of antigen-presenting cells (APC) pulsed with tumor cell membrane fraction to naive syngeneic mice results in effective induction of tumor-specific protective immunity in vivo. The present study examined whether tumor-antigen-pulsed APC can produce the inhibitory effect on the growth of tumor cells when administered to tumor-bearing hosts. Naive BALB/c mice were inoculated with viable tumor cells. Five days later, these mice started to receive the relevant tumor-antigen-pulsed APC at 3- to 4-day intervals. The administration of tumor-antigenpulsed APC induced the rejection or growth inhibition of a growing tumor in approximately half of the recipient mice. Moreover, it was demonstrated that tumor-specific immunity was induced in such tumor-regressed mice. These results indicate that tumor-antigen-pulsed APC are effectively applicable to the tumor-specific immunotherapy. Springer-Verlag, 1992 Tumor-antigen-pulsed cells nationallicence Antigen-presenting cells nationallicence Immunotherapy nationallicence Zou Jian-ping Biomedical Research Center, Osaka University Medical School, 2-2, Yamadaoka, 565, Suita, Osaka, Japan aut Shimizu Jun Biomedical Research Center, Osaka University Medical School, 2-2, Yamadaoka, 565, Suita, Osaka, Japan aut Ikegame Kazuhiro Biomedical Research Center, Osaka University Medical School, 2-2, Yamadaoka, 565, Suita, Osaka, Japan aut Takiuchi Hidekazu Biomedical Research Center, Osaka University Medical School, 2-2, Yamadaoka, 565, Suita, Osaka, Japan aut Fujiwara Hiromi Biomedical Research Center, Osaka University Medical School, 2-2, Yamadaoka, 565, Suita, Osaka, Japan aut Hamaoka Toshiyuki Biomedical Research Center, Osaka University Medical School, 2-2, Yamadaoka, 565, Suita, Osaka, Japan aut Cancer Immunology, Immunotherapy Springer-Verlag 35/1(1992-01-01), 1-6 0340-7004 35:1<1 1992 35 262 https://doi.org/10.1007/BF01741047 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01741047 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Zou Jian-ping Biomedical Research Center, Osaka University Medical School, 2-2, Yamadaoka, 565, Suita, Osaka, Japan aut NATIONALLICENCE 700 1- Shimizu Jun Biomedical Research Center, Osaka University Medical School, 2-2, Yamadaoka, 565, Suita, Osaka, Japan aut NATIONALLICENCE 700 1- Ikegame Kazuhiro Biomedical Research Center, Osaka University Medical School, 2-2, Yamadaoka, 565, Suita, Osaka, Japan aut NATIONALLICENCE 700 1- Takiuchi Hidekazu Biomedical Research Center, Osaka University Medical School, 2-2, Yamadaoka, 565, Suita, Osaka, Japan aut NATIONALLICENCE 700 1- Fujiwara Hiromi Biomedical Research Center, Osaka University Medical School, 2-2, Yamadaoka, 565, Suita, Osaka, Japan aut NATIONALLICENCE 700 1- Hamaoka Toshiyuki Biomedical Research Center, Osaka University Medical School, 2-2, Yamadaoka, 565, Suita, Osaka, Japan aut NATIONALLICENCE 773 0- Cancer Immunology, Immunotherapy Springer-Verlag 35/1(1992-01-01), 1-6 0340-7004 35:1<1 1992 35 262 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer