caa a22 4500 469073535 CHVBK 20180323132928.0 cr unu---uuuuu 170328e19920101xx s 000 0 eng 10.1007/BF01741058 doi (NATIONALLICENCE)springer-10.1007/BF01741058 Photo-immunotargeting with haematoporphyrin conjugates activated by a low-power He-Ne laser [Elektronische Daten] [Timea Berki, Péter Németh] Summary: A combined method has been developed for selective cytolysis in vitro as well as in vivo using a photosensitizer haematoporphyrin-protein conjugate as the targeting molecule and low-power He-Ne laser (632.8 nm) irradiation in order to activate the sensitizer to its excited, toxic triplet energy state. The specificity of the procedure was demonstrated in vitro by purging a mixed cell population from one component, and in vivo in an animal (nude mice) xenograft tumour model, where human cancer cells were destroyed by the immunotargeting method using monoclonal-antibody-haematoporphyrin (mAb-HP) conjugate (a-PNAr-I mAbs, which bind to the cell surface antigens of gastric cancer cells) and soft laser irradiation. The cell destruction was dependent on the doses of both mAb-HP and He-Ne laser light energy, and occurred only in target cell populations. Springer-Verlag, 1992 Photosensitization nationallicence Immunotargeting nationallicence He-Ne laser nationallicence Haematoporphyrin conjugates nationallicence Berki Timea Immunological and Biotechnological Laboratory, University Medical School of Pécs, Szigeti ut 12, H-7643, Pécs, Hungary aut Németh Péter Immunological and Biotechnological Laboratory, University Medical School of Pécs, Szigeti ut 12, H-7643, Pécs, Hungary aut Cancer Immunology, Immunotherapy Springer-Verlag 35/1(1992-01-01), 69-74 0340-7004 35:1<69 1992 35 262 https://doi.org/10.1007/BF01741058 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01741058 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Berki Timea Immunological and Biotechnological Laboratory, University Medical School of Pécs, Szigeti ut 12, H-7643, Pécs, Hungary aut NATIONALLICENCE 700 1- Németh Péter Immunological and Biotechnological Laboratory, University Medical School of Pécs, Szigeti ut 12, H-7643, Pécs, Hungary aut NATIONALLICENCE 773 0- Cancer Immunology, Immunotherapy Springer-Verlag 35/1(1992-01-01), 69-74 0340-7004 35:1<69 1992 35 262 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer