caa a22 4500 469073861 CHVBK 20180323132929.0 cr unu---uuuuu 170328e19920701xx s 000 0 eng 10.1007/BF01789334 doi (NATIONALLICENCE)springer-10.1007/BF01789334 Cellular immunosuppression in children with acute lymphoblastic leukemia: Effect of consolidation chemotherapy [Elektronische Daten] [Yoshihiro Komada, Shao-Li Zhang, Yan-Wen Zhou, Motoi Hanada, Takeo Shibata, Eiichi Azuma, Minoru Sakurai] Summary: The present study was designed to evaluate the chemotherapy-induced cellular immunosuppression in 20 children with acute lymphoblastic leukemia (ALL) in remission and receiving maintenance chemotherapy. Peripheral blood was serially obtained from leukemic children during vincristine/cyclophosphamide/6-mercaptopurine/prednisone combined consolidation chemotherapy. The mean absolute number of peripheral blood lymphocytes as well as the mean absolute numbers of lymphocyte subsets (T cells, T cell subsets, B cells, and natural killer cells) from leukemic children before consolidation chemotherapy were all significantly lower than in control subjects; however, the percentages of lymphocyte subsets were similar in both groups. After consolidation chemotherapy, the percentages of CD4+ T lymphocytes and natural killer (NK) cells were significantly decreased and the percentages of monocytes and CD8+ T lymphocytes were significantly increased. Phytohemagglutinin- and 12-O-tetradecanoylphorbol-13-acetate-induced production of interleukin-2 (IL-2) and NK-cell-mediated cytotoxic activity by peripheral blood mononuclear cells (PBMC) were also substantially decreased in the post-therapy groups. NK activity correlated with the percentage of NK cells in PBMC. In contrast, OK432-induced production of tumor necrosis factor α (TNFα) and killer activity against NK-resistant target cells were significantly increased after therapy as compared with the pre-therapy and control groups. TNFα production correlated with the percentage of monocytes in PBMC. These results demonstrate that substantial quantitative and qualitative chemotherapy-induced abnormalities of the cellular immune system are present in the majority of patients treated with ALL. It is also suggested that the increased TNFα production by monocytes and the appearance of potent killing activity against NK-resistant targets might compensate for the defects of IL-2 production and NK activity during intensive consolidation chemotherapy. Springer-Verlag, 1992 Immunosuppression nationallicence Chemotherapy nationallicence Acute lymphoblastic leukemia nationallicence Komada Yoshihiro Department of Pediatrics, Mie University School of Medicine, 2-174 Edobashi, 514, Tsu, Mie-ken, Japan aut Zhang Shao-Li Department of Pediatrics, Mie University School of Medicine, 2-174 Edobashi, 514, Tsu, Mie-ken, Japan aut Zhou Yan-Wen Department of Pediatrics, Mie University School of Medicine, 2-174 Edobashi, 514, Tsu, Mie-ken, Japan aut Hanada Motoi Department of Pediatrics, Mie University School of Medicine, 2-174 Edobashi, 514, Tsu, Mie-ken, Japan aut Shibata Takeo Department of Pediatrics, Mie University School of Medicine, 2-174 Edobashi, 514, Tsu, Mie-ken, Japan aut Azuma Eiichi Department of Pediatrics, Mie University School of Medicine, 2-174 Edobashi, 514, Tsu, Mie-ken, Japan aut Sakurai Minoru Department of Pediatrics, Mie University School of Medicine, 2-174 Edobashi, 514, Tsu, Mie-ken, Japan aut Cancer Immunology, Immunotherapy Springer-Verlag 35/4(1992-07-01), 271-276 0340-7004 35:4<271 1992 35 262 https://doi.org/10.1007/BF01789334 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01789334 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Komada Yoshihiro Department of Pediatrics, Mie University School of Medicine, 2-174 Edobashi, 514, Tsu, Mie-ken, Japan aut NATIONALLICENCE 700 1- Zhang Shao-Li Department of Pediatrics, Mie University School of Medicine, 2-174 Edobashi, 514, Tsu, Mie-ken, Japan aut NATIONALLICENCE 700 1- Zhou Yan-Wen Department of Pediatrics, Mie University School of Medicine, 2-174 Edobashi, 514, Tsu, Mie-ken, Japan aut NATIONALLICENCE 700 1- Hanada Motoi Department of Pediatrics, Mie University School of Medicine, 2-174 Edobashi, 514, Tsu, Mie-ken, Japan aut NATIONALLICENCE 700 1- Shibata Takeo Department of Pediatrics, Mie University School of Medicine, 2-174 Edobashi, 514, Tsu, Mie-ken, Japan aut NATIONALLICENCE 700 1- Azuma Eiichi Department of Pediatrics, Mie University School of Medicine, 2-174 Edobashi, 514, Tsu, Mie-ken, Japan aut NATIONALLICENCE 700 1- Sakurai Minoru Department of Pediatrics, Mie University School of Medicine, 2-174 Edobashi, 514, Tsu, Mie-ken, Japan aut NATIONALLICENCE 773 0- Cancer Immunology, Immunotherapy Springer-Verlag 35/4(1992-07-01), 271-276 0340-7004 35:4<271 1992 35 262 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer