caa a22 4500 469074027 CHVBK 20180323132930.0 cr unu---uuuuu 170328e19920301xx s 000 0 eng 10.1007/BF01741853 doi (NATIONALLICENCE)springer-10.1007/BF01741853 Enhancement of rat hepatic macrophages by treatment with interleukin-2 and streptococcal preparation OK432, with reference to antitumor activity, soluble factor production and Ia expression [Elektronische Daten] [Tetsu Sasaoki, Shigeki Arii, Kazunobu Monden, Shigeyuki Itai, Yukito Adachi, Naomi Funaki, Hiroaki Higashituji, Takayoshi Tobe] Summary: The effect of biological response modifiers, such as interleukin-2 (IL-2) and streptococcal preparation OK432, on the functions of hepatic macrophages was investigated. The macrophages, even with no exogenous stimulation, produced superoxide anion (O 2 - ) and tumor necrosis factor (TNF), displayed cytotoxicity against K562 cells and cytostasis against P815 cells and expressed immune-region-associated antigen (Ia). IL-2 administered in vitro or in vivo enhanced O 2 - production by hepatic macrophages and the intravenous injection of OK432 also enhanced O 2 - production. Furthermore, IL-2 added to the culture medium of hepatic macrophages isolated from OK432-injected rats augmented O 2 - production even more. The TNF production and Ia expression of the macrophages were also increased by the intravenous injection of OK432. As with O 2 - production, the cytotoxicity of the cells was enhanced by OK432 injection or by IL-2 added to the culture medium and the combination of OK432 and IL-2 augmented their cytotoxicity even more. Thus, the present study suggested that IL-2 and OK432 induce the augmentation of the antitumor activity of hepatic macrophages, partly as a result of the increase in production of O 2 - and TNF and Ia expression. Springer-Verlag, 1992 Hepatic macrophages nationallicence Interleukin-2 nationallicence OK432 nationallicence Antitumor activity nationallicence Sasaoki Tetsu First Department of Surgery, Kyoto University School of Medicine, 54 Shogoin Kawara-cho, Sakyo-ku, 606, Kyoto, Japan aut Arii Shigeki First Department of Surgery, Kyoto University School of Medicine, 54 Shogoin Kawara-cho, Sakyo-ku, 606, Kyoto, Japan aut Monden Kazunobu First Department of Surgery, Kyoto University School of Medicine, 54 Shogoin Kawara-cho, Sakyo-ku, 606, Kyoto, Japan aut Itai Shigeyuki First Department of Surgery, Kyoto University School of Medicine, 54 Shogoin Kawara-cho, Sakyo-ku, 606, Kyoto, Japan aut Adachi Yukito First Department of Surgery, Kyoto University School of Medicine, 54 Shogoin Kawara-cho, Sakyo-ku, 606, Kyoto, Japan aut Funaki Naomi First Department of Surgery, Kyoto University School of Medicine, 54 Shogoin Kawara-cho, Sakyo-ku, 606, Kyoto, Japan aut Higashituji Hiroaki First Department of Surgery, Kyoto University School of Medicine, 54 Shogoin Kawara-cho, Sakyo-ku, 606, Kyoto, Japan aut Tobe Takayoshi First Department of Surgery, Kyoto University School of Medicine, 54 Shogoin Kawara-cho, Sakyo-ku, 606, Kyoto, Japan aut Cancer Immunology, Immunotherapy Springer-Verlag 35/2(1992-03-01), 75-82 0340-7004 35:2<75 1992 35 262 https://doi.org/10.1007/BF01741853 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01741853 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Sasaoki Tetsu First Department of Surgery, Kyoto University School of Medicine, 54 Shogoin Kawara-cho, Sakyo-ku, 606, Kyoto, Japan aut NATIONALLICENCE 700 1- Arii Shigeki First Department of Surgery, Kyoto University School of Medicine, 54 Shogoin Kawara-cho, Sakyo-ku, 606, Kyoto, Japan aut NATIONALLICENCE 700 1- Monden Kazunobu First Department of Surgery, Kyoto University School of Medicine, 54 Shogoin Kawara-cho, Sakyo-ku, 606, Kyoto, Japan aut NATIONALLICENCE 700 1- Itai Shigeyuki First Department of Surgery, Kyoto University School of Medicine, 54 Shogoin Kawara-cho, Sakyo-ku, 606, Kyoto, Japan aut NATIONALLICENCE 700 1- Adachi Yukito First Department of Surgery, Kyoto University School of Medicine, 54 Shogoin Kawara-cho, Sakyo-ku, 606, Kyoto, Japan aut NATIONALLICENCE 700 1- Funaki Naomi First Department of Surgery, Kyoto University School of Medicine, 54 Shogoin Kawara-cho, Sakyo-ku, 606, Kyoto, Japan aut NATIONALLICENCE 700 1- Higashituji Hiroaki First Department of Surgery, Kyoto University School of Medicine, 54 Shogoin Kawara-cho, Sakyo-ku, 606, Kyoto, Japan aut NATIONALLICENCE 700 1- Tobe Takayoshi First Department of Surgery, Kyoto University School of Medicine, 54 Shogoin Kawara-cho, Sakyo-ku, 606, Kyoto, Japan aut NATIONALLICENCE 773 0- Cancer Immunology, Immunotherapy Springer-Verlag 35/2(1992-03-01), 75-82 0340-7004 35:2<75 1992 35 262 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer