caa a22 4500 469074035 CHVBK 20180323132930.0 cr unu---uuuuu 170328e19920301xx s 000 0 eng 10.1007/BF01741858 doi (NATIONALLICENCE)springer-10.1007/BF01741858 Idiotype network components are involved in the murine immune response to simian virus 40 large tumor antigen [Elektronische Daten] [Raymond Mernaugh, Michael Shearer, Robert Bright, Robert Lanford, Ronald Kennedy] Summary: Baculovirus-derived recombinant simian virus 40 (SV40) large tumor antigen (SV40 T-Ag), a monoclonal antibody specific for SV40 T-Ag (Ab-1 preparation), and a monoclonal anti-idiotypic antibody (anti-Id), designated 58D, were used to analyze the humoral immune response of Balb/c mice either immunized with recombinant SV40 T-Ag or challenged with SV40-transformed cells. Inhibition assays indicated that antibodies from mice immunized with SV40 T-Ag and from those bearing SV40 tumor inhibited the SV40 T-Ag/Ab-1 reaction. These data suggested that the antibody response in immunized or tumorchallenged mice recognized similar epitope(s) on SV40 T-Ag to that detected by the monoclonal Ab-1. These anti-(SV40 T-Ag) response antibodies also inhibited the Ab-1/anti-Id reaction and recognized the anti-Id in direct binding assays. Together, these data indicate that murine anti-(SV40 T-Ag) responses shared an idiotope with a monoclonal anti-(SV40 T-Ag) Ab-1 preparation. This idiotope, which is recognized by the monoclonal anti-Id preparation, 58D, appears to be involved in the humoral immune response to SV40 T-Ag in both SV40-T-Ag-immunized and tumor-bearing mice. The monoclonal anti-Id preparation may represent a focal point for manipulating the humoral immune response to tumors induced by SV40-transformed cells. Springer-Verlag, 1992 Idiotype components nationallicence Simian virus 40 nationallicence Mernaugh Raymond Department of Virology and Immunology, Southwest Foundation for Biomedical Research, P. O. Box 28147, 78228-0147, San Antonio, TX, USA aut Shearer Michael Department of Virology and Immunology, Southwest Foundation for Biomedical Research, P. O. Box 28147, 78228-0147, San Antonio, TX, USA aut Bright Robert Department of Virology and Immunology, Southwest Foundation for Biomedical Research, P. O. Box 28147, 78228-0147, San Antonio, TX, USA aut Lanford Robert Department of Virology and Immunology, Southwest Foundation for Biomedical Research, P. O. Box 28147, 78228-0147, San Antonio, TX, USA aut Kennedy Ronald Department of Virology and Immunology, Southwest Foundation for Biomedical Research, P. O. Box 28147, 78228-0147, San Antonio, TX, USA aut Cancer Immunology, Immunotherapy Springer-Verlag 35/2(1992-03-01), 113-118 0340-7004 35:2<113 1992 35 262 https://doi.org/10.1007/BF01741858 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01741858 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Mernaugh Raymond Department of Virology and Immunology, Southwest Foundation for Biomedical Research, P. O. Box 28147, 78228-0147, San Antonio, TX, USA aut NATIONALLICENCE 700 1- Shearer Michael Department of Virology and Immunology, Southwest Foundation for Biomedical Research, P. O. Box 28147, 78228-0147, San Antonio, TX, USA aut NATIONALLICENCE 700 1- Bright Robert Department of Virology and Immunology, Southwest Foundation for Biomedical Research, P. O. Box 28147, 78228-0147, San Antonio, TX, USA aut NATIONALLICENCE 700 1- Lanford Robert Department of Virology and Immunology, Southwest Foundation for Biomedical Research, P. O. Box 28147, 78228-0147, San Antonio, TX, USA aut NATIONALLICENCE 700 1- Kennedy Ronald Department of Virology and Immunology, Southwest Foundation for Biomedical Research, P. O. Box 28147, 78228-0147, San Antonio, TX, USA aut NATIONALLICENCE 773 0- Cancer Immunology, Immunotherapy Springer-Verlag 35/2(1992-03-01), 113-118 0340-7004 35:2<113 1992 35 262 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer