caa a22 4500 469074175 CHVBK 20180323132930.0 cr unu---uuuuu 170328e19921101xx s 000 0 eng 10.1007/BF01741749 doi (NATIONALLICENCE)springer-10.1007/BF01741749 Effect of Nocardia rubra cell-wall skeleton on cancer prevention in humans [Elektronische Daten] [Michio Yamakido, Shinichi Ishioka, Soichiro Hozawa, Shigeru Matsuzaka, Jitsuro Yanagida, Takuzo Shigenobu, Masanori Otake, Yukio Nishimoto] Summary: The retired workers at the chemical weapons plant in Japan are regarded as a high-risk group for cancers. Under the Cancer Preventive Program,Nocardia rubra cell-wall skeleton (N-CWS) was administered to 80 workers directly involved in the production of sulfur mustard and 66 workers engaged in work related to sulfur mustard production. Untreated workers whose age, sex, duties and duration of work at this factory were individually matched to the N-CWS-treated workers were used as controls. During a 4.5-year observation period, development of cancers was found in 7 treated workers and 17 untreated controls. After elimination of the influence of the difference in smoking level, the incidence of subjects who developed cancers was compared statistically between the N-CWS-treated workers and the untreated controls and a significant suppression of development of cancers was noted in the N-CWS-treated workers. Thus, it was concluded that the administration of N-CWS could prevent cancer development in humans. Springer-Verlag, 1992 Chemical weapons nationallicence Sulfur mustard nationallicence Nocardia rubra cell-wall skeleton (N-CWS) nationallicence Cancer prevention nationallicence Yamakido Michio 2nd Department of Internal Medicine, Hiroshima University School of Medicine, 1-2-3 Kasumi, Minami-ku, 734, Hiroshima, Japan aut Ishioka Shinichi 2nd Department of Internal Medicine, Hiroshima University School of Medicine, 1-2-3 Kasumi, Minami-ku, 734, Hiroshima, Japan aut Hozawa Soichiro 2nd Department of Internal Medicine, Hiroshima University School of Medicine, 1-2-3 Kasumi, Minami-ku, 734, Hiroshima, Japan aut Matsuzaka Shigeru 2nd Department of Internal Medicine, Hiroshima University School of Medicine, 1-2-3 Kasumi, Minami-ku, 734, Hiroshima, Japan aut Yanagida Jitsuro 2nd Department of Internal Medicine, Hiroshima University School of Medicine, 1-2-3 Kasumi, Minami-ku, 734, Hiroshima, Japan aut Shigenobu Takuzo 2nd Department of Internal Medicine, Hiroshima University School of Medicine, 1-2-3 Kasumi, Minami-ku, 734, Hiroshima, Japan aut Otake Masanori Department of Epidemiology, Radiation Effects Research Foundation, Hiroshima, Japan aut Nishimoto Yukio 2nd Department of Internal Medicine, Hiroshima University School of Medicine, 1-2-3 Kasumi, Minami-ku, 734, Hiroshima, Japan aut Cancer Immunology, Immunotherapy Springer-Verlag 34/6(1992-11-01), 389-392 0340-7004 34:6<389 1992 34 262 https://doi.org/10.1007/BF01741749 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01741749 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Yamakido Michio 2nd Department of Internal Medicine, Hiroshima University School of Medicine, 1-2-3 Kasumi, Minami-ku, 734, Hiroshima, Japan aut NATIONALLICENCE 700 1- Ishioka Shinichi 2nd Department of Internal Medicine, Hiroshima University School of Medicine, 1-2-3 Kasumi, Minami-ku, 734, Hiroshima, Japan aut NATIONALLICENCE 700 1- Hozawa Soichiro 2nd Department of Internal Medicine, Hiroshima University School of Medicine, 1-2-3 Kasumi, Minami-ku, 734, Hiroshima, Japan aut NATIONALLICENCE 700 1- Matsuzaka Shigeru 2nd Department of Internal Medicine, Hiroshima University School of Medicine, 1-2-3 Kasumi, Minami-ku, 734, Hiroshima, Japan aut NATIONALLICENCE 700 1- Yanagida Jitsuro 2nd Department of Internal Medicine, Hiroshima University School of Medicine, 1-2-3 Kasumi, Minami-ku, 734, Hiroshima, Japan aut NATIONALLICENCE 700 1- Shigenobu Takuzo 2nd Department of Internal Medicine, Hiroshima University School of Medicine, 1-2-3 Kasumi, Minami-ku, 734, Hiroshima, Japan aut NATIONALLICENCE 700 1- Otake Masanori Department of Epidemiology, Radiation Effects Research Foundation, Hiroshima, Japan aut NATIONALLICENCE 700 1- Nishimoto Yukio 2nd Department of Internal Medicine, Hiroshima University School of Medicine, 1-2-3 Kasumi, Minami-ku, 734, Hiroshima, Japan aut NATIONALLICENCE 773 0- Cancer Immunology, Immunotherapy Springer-Verlag 34/6(1992-11-01), 389-392 0340-7004 34:6<389 1992 34 262 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer