caa a22 4500 469074221 CHVBK 20180323132930.0 cr unu---uuuuu 170328e19921101xx s 000 0 eng 10.1007/BF01741744 doi (NATIONALLICENCE)springer-10.1007/BF01741744 Differential effects of human blood monocytes on the growth of human tumour cell lines in vitro [Elektronische Daten] [Heather Parry, Robert Rees] Summary: Monocytes and macrophages have been shown to be cytotoxic towards tumour cells in vitro. However, although tumour-associated monocytes and macrophages are now widely accepted to contribute a relatively high proportion of the cellular infiltrate of experimental and human solid carcinomas, a cytotoxic/cytostatic effector function for these cells in vitro or in vivo has yet to be conclusively demonstrated. In the present study, we show that non-activated peripheral blood monocytes co-cultured with tumour cells across a semi-permeable membrane release soluble factors that modulate the growth of tumour cells in contrasting ways. After Nycoprep 1.068 separation, non-activated peripheral blood monocytes enhanced the in vitro proliferation of HT29 colon adenocarcinoma cells but inhibited T47D breast carcinoma cell replication; peripheral blood lymphocytes were incapable of mediating these effects. In contrast, peripheral blood monocytes activated by interferon γ caused a pronounced inhibition of both HT29 and T47D cell proliferation. Springer-Verlag, 1992 Human blood monocytes nationallicence Tumour cells nationallicence Growth modulation nationallicence Parry Heather Institute of Cancer Studies, Department of Experimental and Clinical Microbiology, Section of Tumour Biology and Immunology, University of Sheffield Medical School, Beech Hill Road, S10 2RX, Sheffield, South Yorkshire, UK aut Rees Robert Institute of Cancer Studies, Department of Experimental and Clinical Microbiology, Section of Tumour Biology and Immunology, University of Sheffield Medical School, Beech Hill Road, S10 2RX, Sheffield, South Yorkshire, UK aut Cancer Immunology, Immunotherapy Springer-Verlag 34/6(1992-11-01), 355-360 0340-7004 34:6<355 1992 34 262 https://doi.org/10.1007/BF01741744 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01741744 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Parry Heather Institute of Cancer Studies, Department of Experimental and Clinical Microbiology, Section of Tumour Biology and Immunology, University of Sheffield Medical School, Beech Hill Road, S10 2RX, Sheffield, South Yorkshire, UK aut NATIONALLICENCE 700 1- Rees Robert Institute of Cancer Studies, Department of Experimental and Clinical Microbiology, Section of Tumour Biology and Immunology, University of Sheffield Medical School, Beech Hill Road, S10 2RX, Sheffield, South Yorkshire, UK aut NATIONALLICENCE 773 0- Cancer Immunology, Immunotherapy Springer-Verlag 34/6(1992-11-01), 355-360 0340-7004 34:6<355 1992 34 262 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer