caa a22 4500 469074256 CHVBK 20180323132930.0 cr unu---uuuuu 170328e19920701xx s 000 0 eng 10.1007/BF01741788 doi (NATIONALLICENCE)springer-10.1007/BF01741788 Unique histological changes in lung metastases of osteosarcoma patients following therapy with liposomal muramyl tripeptide (CGP 19835A lipid) [Elektronische Daten] [Eugenie Kleinerman, Austin Raymond, Corazon Bucana, Norman Jaffe, Michael Harris, Irwin Krakoff, Robert Benjamin, Isaiah Fidler] Summary: We have recently begun a phase II trial in patients with osteosarcoma who developed pulmonary metastases during adjuvant chemotherapy or who presented with pulmonary metastases that persisted despite chemotherapy. Eligible patients were rendered free of visible disease by surgery. Liposome-encapsulated muramyl tripeptide phosphatidylethanolamine (MTP-PE, CGP 19835A lipid) (2 mg/m2) was infused twice weekly for 3 months. In five patients, a single tumor nodule recurred within 6 weeks after completion of therapy. These lesions were resected and submitted for pathological examination. Tissue specimens obtained after therapy were compared to those obtained before therapy. All the patients showed a histological change in the characteristics of the pulmonary tumors. In three patients, peripheral fibrosis surrounded the tumor and inflammatory cell infiltration and neovascularization were present. This is in contrast to central necrosis, with viable peripheral tumor cells and no inflammatory response observed in lesions resected following chemotherapy. In a fourth case, evidence of early fibrotic changes was found. This and the fifth case showed a change in malignant characteristics, from high grade before liposomal therapy to low grade after therapy. The present study provides evidence for a biological effect of liposomal MTP-PE. Springer-Verlag, 1992 Liposomal therapy nationallicence Fibrosis nationallicence Kleinerman Eugenie Department of Cell Biology, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Boulevard, Box 173, 77 030, Houston, Texas, USA aut Raymond Austin Department of Pathology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas, USA aut Bucana Corazon Department of Cell Biology, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Boulevard, Box 173, 77 030, Houston, Texas, USA aut Jaffe Norman Department of Pediatrics, The University of Texas M. D. Anderson Cancer Center, Houston, Texas, USA aut Harris Michael Tomorrow's Children's Institute, Hackensack, New Yersey, USA aut Krakoff Irwin Department of Division of Medicine, The University of Texas M. D. Anderson Cancer Center, Houston, Texas, USA aut Benjamin Robert Department of Medical Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas, USA aut Fidler Isaiah Department of Cell Biology, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Boulevard, Box 173, 77 030, Houston, Texas, USA aut Cancer Immunology, Immunotherapy Springer-Verlag 34/4(1992-07-01), 211-220 0340-7004 34:4<211 1992 34 262 https://doi.org/10.1007/BF01741788 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01741788 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kleinerman Eugenie Department of Cell Biology, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Boulevard, Box 173, 77 030, Houston, Texas, USA aut NATIONALLICENCE 700 1- Raymond Austin Department of Pathology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas, USA aut NATIONALLICENCE 700 1- Bucana Corazon Department of Cell Biology, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Boulevard, Box 173, 77 030, Houston, Texas, USA aut NATIONALLICENCE 700 1- Jaffe Norman Department of Pediatrics, The University of Texas M. D. Anderson Cancer Center, Houston, Texas, USA aut NATIONALLICENCE 700 1- Harris Michael Tomorrow's Children's Institute, Hackensack, New Yersey, USA aut NATIONALLICENCE 700 1- Krakoff Irwin Department of Division of Medicine, The University of Texas M. D. Anderson Cancer Center, Houston, Texas, USA aut NATIONALLICENCE 700 1- Benjamin Robert Department of Medical Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas, USA aut NATIONALLICENCE 700 1- Fidler Isaiah Department of Cell Biology, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Boulevard, Box 173, 77 030, Houston, Texas, USA aut NATIONALLICENCE 773 0- Cancer Immunology, Immunotherapy Springer-Verlag 34/4(1992-07-01), 211-220 0340-7004 34:4<211 1992 34 262 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer