caa a22 4500 469074329 CHVBK 20180323132931.0 cr unu---uuuuu 170328e19920701xx s 000 0 eng 10.1007/BF01741790 doi (NATIONALLICENCE)springer-10.1007/BF01741790 Effect of anticancer drugs on the release of interleukin-6 in vitro [Elektronische Daten] [S. Hasan, Barbara Blaney, J. Turk] Summary: This study investigates the effects of anticancer drugs and immunomodulating agents on the release of interleukin-6 (IL-6) from lipopolysaccharide-stimulated human peripheral blood mononuclear leucocytes in vitro. The addition of non-cytotoxic concentrations of Adriamycin (doxorubicin), vincristine and 4-OOH-cyclophosphamide (the in vitro active analogue of cyclophosphamide) resulted in suppression of IL-6 release. The drugs bleomycin, FK156 [d-lactoyl-l-alanyl-γ-d-glutamyl-(l)-meso-diaminopimelyl-(l)-glycine], FK565 [heptanoyl-γ-d-glutamyl-(l)-meso-diaminopimelyl-(d)-alanine] and the immunosuppressive agent cyclosporin A did not alter the release of IL-6 in the same experimental system. Springer-Verlag, 1992 IL-6 nationallicence Immunomodulation nationallicence Drug inhibition nationallicence Hasan S. The Royal College of Surgeons of England, 35-43 Lincoln's Inn Fields, WC2A 3PN, London, UK aut Blaney Barbara The Royal College of Surgeons of England, 35-43 Lincoln's Inn Fields, WC2A 3PN, London, UK aut Turk J. The Royal College of Surgeons of England, 35-43 Lincoln's Inn Fields, WC2A 3PN, London, UK aut Cancer Immunology, Immunotherapy Springer-Verlag 34/4(1992-07-01), 228-232 0340-7004 34:4<228 1992 34 262 https://doi.org/10.1007/BF01741790 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01741790 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Hasan S. The Royal College of Surgeons of England, 35-43 Lincoln's Inn Fields, WC2A 3PN, London, UK aut NATIONALLICENCE 700 1- Blaney Barbara The Royal College of Surgeons of England, 35-43 Lincoln's Inn Fields, WC2A 3PN, London, UK aut NATIONALLICENCE 700 1- Turk J. The Royal College of Surgeons of England, 35-43 Lincoln's Inn Fields, WC2A 3PN, London, UK aut NATIONALLICENCE 773 0- Cancer Immunology, Immunotherapy Springer-Verlag 34/4(1992-07-01), 228-232 0340-7004 34:4<228 1992 34 262 Metadata rights reserved Springer special CC-BY-NC licence nationallicence SWISSBIB 465691080 BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer