caa a22 4500 469077808 CHVBK 20180323132940.0 cr unu---uuuuu 170328e19920701xx s 000 0 eng 10.1007/BF00167578 doi (NATIONALLICENCE)springer-10.1007/BF00167578 Griesbacher Thomas Department of Experimental and Clinical Pharmacology, University of Graz, Universitätsplatz 4, A-8010, Graz, Austria aut Kinin-induced relaxations of the rat duodenum [Elektronische Daten] [Thomas Griesbacher] Summary: Both bradykinin (BK) and des-Arg9-BK induced relaxations of the isolated longitudinal smooth muscles of the rat duodenum. No contractile effects were observed with both peptides at concentrations up to 1 μmol/l. Des-Arg9-BK was about 1000 times less potent than BK. The novel B2 antagonist HOE 140 (d-Arg-[Hyp3, Thi5, D-Phe7, Oic8]-BK) potently inhibited the BK-induced relaxations, but did not affect the relaxations induced by des-Arg9-BK. Conversely, the B1 receptor antagonist des-Arg9-[Leu8]-BK only inhibited des-Arg9-BK, but did not affect BK-induced relaxations. The relaxations induced by BK and by des-Arg9-BK were inhibited by apamin (1 μmol/l) demonstrating that apamin-sensitive K+ channels are involved. In contrast, tetraethylammonium (1 mmol/l) did not inhibit the relaxations. BK-induced relaxations were reduced by about 25% in the presence of indomethacin (10 μmol/l) although the concentration-response curve to BK was not shifted to the left. Prostaglandin E1 caused relaxations with a pD2 value of 9.2. It is concluded that both BK and des-Arg9-BK can elicit relaxations of the rat duodenum via pharmacologically distinct kinin receptor subtypes, but via similar effector mechanisms. Springer-Verlag, 1992 Bradykinin receptors nationallicence Bradykinin antagonists nationallicence HOE 140 nationallicence Smooth muscle relaxation nationallicence Potassium channels nationallicence Naunyn-Schmiedeberg's Archives of Pharmacology Springer-Verlag 346/1(1992-07-01), 102-107 0028-1298 346:1<102 1992 346 210 https://doi.org/10.1007/BF00167578 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00167578 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Griesbacher Thomas Department of Experimental and Clinical Pharmacology, University of Graz, Universitätsplatz 4, A-8010, Graz, Austria aut NATIONALLICENCE 773 0- Naunyn-Schmiedeberg's Archives of Pharmacology Springer-Verlag 346/1(1992-07-01), 102-107 0028-1298 346:1<102 1992 346 210 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer