caa a22 4500 469077824 CHVBK 20180323132940.0 cr unu---uuuuu 170328e19920701xx s 000 0 eng 10.1007/BF00167566 doi (NATIONALLICENCE)springer-10.1007/BF00167566 Celiprolol exerts microvascular dilatation by activation of β2-adrenoceptors [Elektronische Daten] [Stefan Dhein, Sandra Titzer, Marcus Wallstein, Andreas Müller, Robert Gerwin, Bruno Panzner, Wolfgang Klaus] Summary: In order to clarify the question whether the β1-selective adrenoceptor antagonist celiprolol possesses vasodilating properties, isolated vascular networks were perfused with increasing concentrations of celiprolol (in a cumulative manner) ranging from 10−8 to 10−4 mol/l. The study was carried out using the isolated mesenteric vascular bed of the guinea pig mesenterium coli. Vascular diameters of four different vascular regions [vessels classified as G1 (585 ± 30 μm), G2 (403 ± 25 μm), G3 (282 ± 27 μm) and G4 (197 ± 13 μm)] were assessed by means of microscopic videoangiometry. Perfusion with celiprolol resulted in concentration dependent vasodilation which was more pronounced in G3 and G4 vessels. In addition, cumulative concentration-response curves were determined from responses obtained in the presence of 10−8, 10−7, 10−6 and 10−4 mol/l ICI 118,551 (a highly selective adrenoceptor antagonist). In the presence of ICI 118,551 at concentrations ≥ 10−6 mol/l, no celiprolol response could be observed. Lower concentrations of ICI 118,551 shifted the celiprolol concentration-response curve to the right in a concentration-dependent manner. Therefore, it is concluded (a) that celiprolol has a vasodilating effect, (b) that this vasodilation is produced by stimulation of β2-adrenoceptors and (c) that the vasodilating effect is more pronounced in smaller than in larger vessels (G3, G4 vs G1, G2). Springer-Verlag, 1992 Celiprolol nationallicence β2-adrenoceptors nationallicence Mesenteric artery nationallicence Microcirculation nationallicence Dhein Stefan Institut für Pharmakologie, Universität zu Köln, Gleuelerstrasse 24, W-5000, Köln 41, Federal Republic of Germany aut Titzer Sandra Institut für Pharmakologie, Universität zu Köln, Gleuelerstrasse 24, W-5000, Köln 41, Federal Republic of Germany aut Wallstein Marcus Institut für Pharmakologie, Universität zu Köln, Gleuelerstrasse 24, W-5000, Köln 41, Federal Republic of Germany aut Müller Andreas Institut für Pharmakologie, Universität zu Köln, Gleuelerstrasse 24, W-5000, Köln 41, Federal Republic of Germany aut Gerwin Robert Institut für Pharmakologie, Universität zu Köln, Gleuelerstrasse 24, W-5000, Köln 41, Federal Republic of Germany aut Panzner Bruno Institut für Pharmakologie, Universität zu Köln, Gleuelerstrasse 24, W-5000, Köln 41, Federal Republic of Germany aut Klaus Wolfgang Institut für Pharmakologie, Universität zu Köln, Gleuelerstrasse 24, W-5000, Köln 41, Federal Republic of Germany aut Naunyn-Schmiedeberg's Archives of Pharmacology Springer-Verlag 346/1(1992-07-01), 27-31 0028-1298 346:1<27 1992 346 210 https://doi.org/10.1007/BF00167566 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00167566 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Dhein Stefan Institut für Pharmakologie, Universität zu Köln, Gleuelerstrasse 24, W-5000, Köln 41, Federal Republic of Germany aut NATIONALLICENCE 700 1- Titzer Sandra Institut für Pharmakologie, Universität zu Köln, Gleuelerstrasse 24, W-5000, Köln 41, Federal Republic of Germany aut NATIONALLICENCE 700 1- Wallstein Marcus Institut für Pharmakologie, Universität zu Köln, Gleuelerstrasse 24, W-5000, Köln 41, Federal Republic of Germany aut NATIONALLICENCE 700 1- Müller Andreas Institut für Pharmakologie, Universität zu Köln, Gleuelerstrasse 24, W-5000, Köln 41, Federal Republic of Germany aut NATIONALLICENCE 700 1- Gerwin Robert Institut für Pharmakologie, Universität zu Köln, Gleuelerstrasse 24, W-5000, Köln 41, Federal Republic of Germany aut NATIONALLICENCE 700 1- Panzner Bruno Institut für Pharmakologie, Universität zu Köln, Gleuelerstrasse 24, W-5000, Köln 41, Federal Republic of Germany aut NATIONALLICENCE 700 1- Klaus Wolfgang Institut für Pharmakologie, Universität zu Köln, Gleuelerstrasse 24, W-5000, Köln 41, Federal Republic of Germany aut NATIONALLICENCE 773 0- Naunyn-Schmiedeberg's Archives of Pharmacology Springer-Verlag 346/1(1992-07-01), 27-31 0028-1298 346:1<27 1992 346 210 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer