caa a22 4500 469077921 CHVBK 20180323132940.0 cr unu---uuuuu 170328e19920701xx s 000 0 eng 10.1007/BF00167569 doi (NATIONALLICENCE)springer-10.1007/BF00167569 Inhibition of noradrenaline release from the sympathetic nerves of the human saphenous vein by presynaptic histamine H3 receptors [Elektronische Daten] [G. Molderings, G. Weißenborn, E. Schlicker, J. Likungu, M. Göthert] Summary: The human saphenous vein was used to examine whether presynaptic histamine receptors can modulate noradrenaline release and, if so, to determine their pharmacological characteristics. Strips of this blood vessel were incubated with [3H]noradrenaline and subsequently superfused with physiological salt solution containing desipramine and corticosterone. Electrically (2 Hz) evoked 3H overflow was inhibited by histamine and the H3 receptor agonist R-(−)-α-methylhistamine. Histamine-induced inhibition of electrically evoked tritium overflow was not affected by α2-adrenoceptor blockade by rauwolscine. S-(+)-α-methylhistamine (up to 10 μmol/l) as well as the histamine H1 and H2 receptor agonists 2-(2-thiazolyl)ethylamine (up to 3 μmol/l) and dimaprit (up to 30 μmol/l), respectively, were ineffective. The selective histamine H3 receptor antagonist thioperamide abolished the inhibitory effect of histamine. The histamine H2 and H1 receptor antagonists ranitidine and pheniramine, respectively, did not affect the histamine-induced inhibition of evoked tritium overflow. The present results are compatible with the suggestion that the sympathetic nerves of the human saphenous vein are endowed with inhibitory presynaptic histamine receptors of the H3 class. Springer-Verlag, 1992 Noradrenaline release nationallicence Histamine H3 receptor nationallicence Presynaptic receptors nationallicence Human saphenous vein nationallicence Molderings G. Institut für Pharmakologie und Toxikologie, Rheinische Friedrich-Wilhelms-Universität Bonn, Reuterstrasse 2b, W-5300, Bonn 1, Federal Republic of Germany aut Weißenborn G. Institut für Pharmakologie und Toxikologie, Rheinische Friedrich-Wilhelms-Universität Bonn, Reuterstrasse 2b, W-5300, Bonn 1, Federal Republic of Germany aut Schlicker E. Institut für Pharmakologie und Toxikologie, Rheinische Friedrich-Wilhelms-Universität Bonn, Reuterstrasse 2b, W-5300, Bonn 1, Federal Republic of Germany aut Likungu J. Klinik für Herz- und Gefäßchirurgie, Rheinische Friedrich-Wilhelms-Universität Bonn, Reuterstrasse 2b, W-5300, Bonn 1, Federal Republic of Germany aut Göthert M. Institut für Pharmakologie und Toxikologie, Rheinische Friedrich-Wilhelms-Universität Bonn, Reuterstrasse 2b, W-5300, Bonn 1, Federal Republic of Germany aut Naunyn-Schmiedeberg's Archives of Pharmacology Springer-Verlag 346/1(1992-07-01), 46-50 0028-1298 346:1<46 1992 346 210 https://doi.org/10.1007/BF00167569 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00167569 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Molderings G. Institut für Pharmakologie und Toxikologie, Rheinische Friedrich-Wilhelms-Universität Bonn, Reuterstrasse 2b, W-5300, Bonn 1, Federal Republic of Germany aut NATIONALLICENCE 700 1- Weißenborn G. Institut für Pharmakologie und Toxikologie, Rheinische Friedrich-Wilhelms-Universität Bonn, Reuterstrasse 2b, W-5300, Bonn 1, Federal Republic of Germany aut NATIONALLICENCE 700 1- Schlicker E. Institut für Pharmakologie und Toxikologie, Rheinische Friedrich-Wilhelms-Universität Bonn, Reuterstrasse 2b, W-5300, Bonn 1, Federal Republic of Germany aut NATIONALLICENCE 700 1- Likungu J. Klinik für Herz- und Gefäßchirurgie, Rheinische Friedrich-Wilhelms-Universität Bonn, Reuterstrasse 2b, W-5300, Bonn 1, Federal Republic of Germany aut NATIONALLICENCE 700 1- Göthert M. Institut für Pharmakologie und Toxikologie, Rheinische Friedrich-Wilhelms-Universität Bonn, Reuterstrasse 2b, W-5300, Bonn 1, Federal Republic of Germany aut NATIONALLICENCE 773 0- Naunyn-Schmiedeberg's Archives of Pharmacology Springer-Verlag 346/1(1992-07-01), 46-50 0028-1298 346:1<46 1992 346 210 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer