caa a22 4500 469077972 CHVBK 20180323132940.0 cr unu---uuuuu 170328e19921201xx s 000 0 eng 10.1007/BF00168736 doi (NATIONALLICENCE)springer-10.1007/BF00168736 In vivo evidence for a concordant response of terminal and dendritic dopamine release during intranigral infusion of drugs [Elektronische Daten] [B. Westerink, M. Santiago, J. De Vries] Summary: In the present study we have administered prototypical drugs of 5 different receptors (D-2, GABA-A, GABA-B, NMDA, kainate) to the substantia nigra by infusion via a microdialysis probe, whereas the release of dopamine and 3,4-dihydroxyphenylacetic acid (DOPAC) were recorded both in the substantia nigra and (by a second microdialysis probe) in the ipsilateral striatum. Infusion of the specific D-2 receptor agonist 2-(N-propyl-N-2-thienylethylamino)-5-hydroxytetralin ((-)-N0437) into the nigra induced a decrease in the release of dopamine in the nigra (after 1 μmol/l) as well as in the ipsilateral striatum (after 10 μmol/l). During these infusions extracellular DOPAC decresed in the nigra and increased in the striatum. Infusion of the D-2 specific receptor antagonist (-)-sulpiride into the nigra induced an increase in the release of dopamine in the nigra (after 1 μmol/l) as well as in the ipsilateral striatum (10 μmol/l). During these infusions a slight increase of extracellular DOPAC was noticed in the nigra. Infusion of the GABA-A receptor antagonist bicuculline into the nigra (50 μmol/l) induced an increase in the release of dopamine and DOPAC both in the nigra and ipsilateral striatum. Infusion of the GABA-B receptor agonist d,I-baclofen into the nigra (10 μmol/l) induced a decrease of in the release of dopamine in the nigra as well as in the ipsilateral striatum, whereas extracellular DOPAC decreased in the nigra and increased in the striatum. Infusion of the glutamate receptor agonist N-methyl-D-aspartate (NMDA) into the nigra induced an increase in the release of dopamine and DOPAC in the nigra (after 300 μmol/l) as well as in the ipsilateral striatum (after 1 mmol/l). Infusion of the glutamate receptor agonist kainate into the nigra (10 μmol/l) induced an increase in the release of dopamine and DOPAC in the nigra as well as in the ipsilateral striatum. The results showed that nigral as well as striatal dopamine release respond in a concordant way to intranigral infusion of drugs. Springer-Verlag, 1992 Microdialysis nationallicence Dopamine nationallicence GABA nationallicence Excitatory amino acids nationallicence Substantia nigra nationallicence Westerink B. Department of Medicinal Chemistry, University of Groningen, University Center for Pharmacy, Antonius Deusinglaan, 2, NL-9713 AW, Groningen, The Netherlands aut Santiago M. Department of Pharmacy, University of Sevilla, Sevilla, Spain aut De Vries J. Department of Medicinal Chemistry, University of Groningen, University Center for Pharmacy, Antonius Deusinglaan, 2, NL-9713 AW, Groningen, The Netherlands aut Naunyn-Schmiedeberg's Archives of Pharmacology Springer-Verlag 346/6(1992-12-01), 637-643 0028-1298 346:6<637 1992 346 210 https://doi.org/10.1007/BF00168736 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00168736 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Westerink B. Department of Medicinal Chemistry, University of Groningen, University Center for Pharmacy, Antonius Deusinglaan, 2, NL-9713 AW, Groningen, The Netherlands aut NATIONALLICENCE 700 1- Santiago M. Department of Pharmacy, University of Sevilla, Sevilla, Spain aut NATIONALLICENCE 700 1- De Vries J. Department of Medicinal Chemistry, University of Groningen, University Center for Pharmacy, Antonius Deusinglaan, 2, NL-9713 AW, Groningen, The Netherlands aut NATIONALLICENCE 773 0- Naunyn-Schmiedeberg's Archives of Pharmacology Springer-Verlag 346/6(1992-12-01), 637-643 0028-1298 346:6<637 1992 346 210 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer