caa a22 4500 469077999 CHVBK 20180323132940.0 cr unu---uuuuu 170328e19921201xx s 000 0 eng 10.1007/BF00168746 doi (NATIONALLICENCE)springer-10.1007/BF00168746 Anti-inflammatory and analgesic effects of magnolol [Elektronische Daten] [Jih-Pyang Wang, Mei-Feng Hsu, Shue-Zing Raung, Chen-Chih Chen, Jon-Son Kuo, Che-Ming Teng] Summary: Magnolol, isolated from Magnolia officinalis, inhibited mouse hind-paw edema induced by carrageenan, compound 4880, polymyxin B and reversed passive Arthus reaction. Acetic acid-induced writhing response was depressed by magnolol, indomethacin and ibuprofen. The lethality of endotoxin challenge was reduced by pretreatment with magnolol, indomethacin and BW755C, a dual cyclo-oxygenase/lipoxygenase inhibitor. The recovered myeloperoxidase activity in edematous paw was significantly decreased in mice pretreated with magnolol and BW755C. Suppression of edema was demonstrated not only in normal mice but also in adrenalectomized animals. Magnolol was less potent on reducing PGD2 formation in rat mast cell than that of indomethacin. Unlike dexamethasone, magnolol did not increase liver glycogen level. The results suggest that the anti-inflammatory effect of magnolol was neither mediated by glucocorticoid activity nor through releasing steroid hormones from adrenal gland. The action of magnolol is proposed to be dependent on reducing the level of eicosanoid mediators. Springer-Verlag, 1992 Mice paw edema nationallicence Magnolol nationallicence Eicosanoids nationallicence Analgesia nationallicence Endotoxic mortality nationallicence Wang Jih-Pyang Department of Medical Research, Taichung Veterans General Hospital, Taichung, Taiwan, Republic of China aut Hsu Mei-Feng Department of Biochemistry, China Medical College, Taichung aut Raung Shue-Zing Department of Medical Research, Taichung Veterans General Hospital, Taichung, Taiwan, Republic of China aut Chen Chen-Chih National Research Institute of Chinese Medicine, Taipei aut Kuo Jon-Son Department of Medical Research, Taichung Veterans General Hospital, Taichung, Taiwan, Republic of China aut Teng Che-Ming Pharmacological Institute, College of Medicine, National Taiwan University, Taipei, Taiwan, Republic of China aut Naunyn-Schmiedeberg's Archives of Pharmacology Springer-Verlag 346/6(1992-12-01), 707-712 0028-1298 346:6<707 1992 346 210 https://doi.org/10.1007/BF00168746 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00168746 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Wang Jih-Pyang Department of Medical Research, Taichung Veterans General Hospital, Taichung, Taiwan, Republic of China aut NATIONALLICENCE 700 1- Hsu Mei-Feng Department of Biochemistry, China Medical College, Taichung aut NATIONALLICENCE 700 1- Raung Shue-Zing Department of Medical Research, Taichung Veterans General Hospital, Taichung, Taiwan, Republic of China aut NATIONALLICENCE 700 1- Chen Chen-Chih National Research Institute of Chinese Medicine, Taipei aut NATIONALLICENCE 700 1- Kuo Jon-Son Department of Medical Research, Taichung Veterans General Hospital, Taichung, Taiwan, Republic of China aut NATIONALLICENCE 700 1- Teng Che-Ming Pharmacological Institute, College of Medicine, National Taiwan University, Taipei, Taiwan, Republic of China aut NATIONALLICENCE 773 0- Naunyn-Schmiedeberg's Archives of Pharmacology Springer-Verlag 346/6(1992-12-01), 707-712 0028-1298 346:6<707 1992 346 210 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer