caa a22 4500 469078030 CHVBK 20180323132940.0 cr unu---uuuuu 170328e19921201xx s 000 0 eng 10.1007/BF00168745 doi (NATIONALLICENCE)springer-10.1007/BF00168745 Erythromycin and motilin stimulate sphincter of Oddi motility and inhibit trans-sphincteric flow in the Australian possum [Elektronische Daten] [Gino Saccone, Yong-Feng Liu, Anders Thune, John Harvey, Robert Baker, James Toouli] Summary: The actions of erythromycin lactobionate and porcine motilin on trans-sphincteric flow and simultaneous sphincter of Oddi motility were studied in 15 anaesthetized Australian Brush-tailed possums (Trichosurus vulpecula). Erythromycin (25-200 μg/kg) and motilin (25-200 ng/kg) were administered as graded doses by close intraarterial injection. Trans-sphincteric flow was measured as inflow and outflow. Both motilin and erythromycin decreased trans-sphincteric inflow (both P<0.0001) and outflow (P<0.0001 and P=0.0017 respectively) in a dose-dependent manner. The highest dose of each agent abolished trans-sphincteric flow. These agents increased sphincter of Oddi phasic contraction frequency and basal pressure up to 2 and 3 fold respectively (P<0.05). The amplitude of the sphincter of Oddi phasic contractions were not influenced in any consistent fashion by either agent. The durations of the responses (trans-sphincteric inflow) elicited by erythromycin and motilin were dose dependent (P = 0.0225 and P = 0.0001 respectively). The actions of erythromycin (200 μg/kg) or motilin (100 ng/kg) on trans-sphincteric flow and sphincter of Oddi motility were not influenced by neural blockade with tetrodotoxin. These findings support the hypothesis that erythromycin acts as a motilin agonist and both substances increase the resistance to flow through the sphincter of Oddi by raising the basal pressure and frequency of contractions. Springer-Verlag, 1992 Biliary motility nationallicence Erythromycin nationallicence Motilin nationallicence Tetrodotoxin nationallicence Saccone Gino Department of Surgery, Flinders Medical Centre, Bedford Park, 5042, South Australia, Australia aut Liu Yong-Feng Department of Surgery, Flinders Medical Centre, Bedford Park, 5042, South Australia, Australia aut Thune Anders Department of Surgery, Flinders Medical Centre, Bedford Park, 5042, South Australia, Australia aut Harvey John Department of Surgery, Flinders Medical Centre, Bedford Park, 5042, South Australia, Australia aut Baker Robert Department of Surgery, Flinders Medical Centre, Bedford Park, 5042, South Australia, Australia aut Toouli James Department of Surgery, Flinders Medical Centre, Bedford Park, 5042, South Australia, Australia aut Naunyn-Schmiedeberg's Archives of Pharmacology Springer-Verlag 346/6(1992-12-01), 701-706 0028-1298 346:6<701 1992 346 210 https://doi.org/10.1007/BF00168745 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00168745 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Saccone Gino Department of Surgery, Flinders Medical Centre, Bedford Park, 5042, South Australia, Australia aut NATIONALLICENCE 700 1- Liu Yong-Feng Department of Surgery, Flinders Medical Centre, Bedford Park, 5042, South Australia, Australia aut NATIONALLICENCE 700 1- Thune Anders Department of Surgery, Flinders Medical Centre, Bedford Park, 5042, South Australia, Australia aut NATIONALLICENCE 700 1- Harvey John Department of Surgery, Flinders Medical Centre, Bedford Park, 5042, South Australia, Australia aut NATIONALLICENCE 700 1- Baker Robert Department of Surgery, Flinders Medical Centre, Bedford Park, 5042, South Australia, Australia aut NATIONALLICENCE 700 1- Toouli James Department of Surgery, Flinders Medical Centre, Bedford Park, 5042, South Australia, Australia aut NATIONALLICENCE 773 0- Naunyn-Schmiedeberg's Archives of Pharmacology Springer-Verlag 346/6(1992-12-01), 701-706 0028-1298 346:6<701 1992 346 210 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer