caa a22 4500 469078219 CHVBK 20180323132941.0 cr unu---uuuuu 170328e19920901xx s 000 0 eng 10.1007/BF00173549 doi (NATIONALLICENCE)springer-10.1007/BF00173549 Effects of the novel calcium channel blocker, anipamil, on the isolated rabbit heart [Elektronische Daten] Comparison with verapamil and gallopamil [Riccardo Raddino, Enzo Poli, Evasio Pasini, Roberto Ferrari] Summary: The calcium channel blocking activity of the novel phenylalkylamine derivative, anipamil, was tested on the isolated rabbit heart, in comparison with verapamil and gallopamil. Anipamil and the other calcium channel blockers lower left ventricular pressure in the same concentration range (10−8 -10−4 mol/1). The negative inotropic effect of anipamil is only partially reversed (nearly 65%) by rising calcium concentration in the perfusion fluid, whilst a complete recovery is observed for verapamil and gallopamil. The negative inotropic effect of anipamil is of rapid onset but long lasting, being still present 12 h after washout. On the contrary, that of gallopamil or verapamil completely disappears within 3 h of washout. Verapamil and gallopamil (10−8 -10−4 mol/1) depress spontaneous heart rate up to asystolia and abolish the vasopressin- and Bay K 8644-induced coronary spasm. Anipamil, on the contrary, does not modify coronary spasm elicited by both stimulants and spontaneous heart rate up to 10−4 mol/l. These observations suggest that anipamil, in the isolated rabbit heart, possesses a peculiar pharmacological profile, since its calcium channel blocking activity is confined to the myocardial muscle. Springer-Verlag, 1992 Anipamil nationallicence Verapamil nationallicence Gallopamil nationallicence Calcium channels nationallicence Isolated rabbit heart nationallicence Raddino Riccardo Department of Cardiology, University of Brescia, P. le Spedali Civili, 1, I-25100, Brescia, Italy aut Poli Enzo Institute of Pharmacology, University of Parma, Via Gramsci, 14, Ospedale Maggiore, I-43100, Parma, Italy aut Pasini Evasio Department of Cardiology, University of Brescia, P. le Spedali Civili, 1, I-25100, Brescia, Italy aut Ferrari Roberto Department of Cardiology, University of Brescia, P. le Spedali Civili, 1, I-25100, Brescia, Italy aut Naunyn-Schmiedeberg's Archives of Pharmacology Springer-Verlag 346/3(1992-09-01), 339-344 0028-1298 346:3<339 1992 346 210 https://doi.org/10.1007/BF00173549 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00173549 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Raddino Riccardo Department of Cardiology, University of Brescia, P. le Spedali Civili, 1, I-25100, Brescia, Italy aut NATIONALLICENCE 700 1- Poli Enzo Institute of Pharmacology, University of Parma, Via Gramsci, 14, Ospedale Maggiore, I-43100, Parma, Italy aut NATIONALLICENCE 700 1- Pasini Evasio Department of Cardiology, University of Brescia, P. le Spedali Civili, 1, I-25100, Brescia, Italy aut NATIONALLICENCE 700 1- Ferrari Roberto Department of Cardiology, University of Brescia, P. le Spedali Civili, 1, I-25100, Brescia, Italy aut NATIONALLICENCE 773 0- Naunyn-Schmiedeberg's Archives of Pharmacology Springer-Verlag 346/3(1992-09-01), 339-344 0028-1298 346:3<339 1992 346 210 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer