caa a22 4500 469078340 CHVBK 20180323132941.0 cr unu---uuuuu 170328e19921001xx s 000 0 eng 10.1007/BF00171082 doi (NATIONALLICENCE)springer-10.1007/BF00171082 Effect of ageing on the number of neuronal noradrenaline uptake sites in the rat vas deferens [Elektronische Daten] [Regina Markus, Maria de Werneck] Summary: Previous work has shown an age-related reduction in neuronal uptake of noradrenaline in the prostatic, but not in the epididymal portion of the rat vas deferens. In the present paper, the influence of ageing on the number of [3H]desipramine binding sites and on the effect of lithium on neuronal [3H]noradrenaline uptake were studied in the prostatic and epididymal portions of vasa deferentia from 4- and 20-month-old rats. The affinity for [3H]desipramine (K d values) in the epididymal and prostatic portions did not change with age. However, ageing reduced the maximal number of [3H]desipramine binding sites (Bmax values) in the prostatic, but not in the epididymal portion. Lithium potentiated neuronal [3H]noradrenaline uptake only in the prostatic portion and this potentiation was not changed by ageing. The results showed differences in neuronal noradrenaline uptake between the two portions of the vas deferens. Furthermore, the data suggest that the age-related reduction in neuronal uptake in the prostatic portion is due to a reduction in the number of neuronal uptake sites for noradrenaline. Springer-Verlag, 1992 Vas deferens nationallicence Age-related changes nationallicence Neuronal uptake nationallicence Noradrenaline nationallicence Desipraminebinding sites nationallicence Markus Regina Departamento de Farmacologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, Av. Lineu Prestes 1524, 05508, São Paulo, Brasil aut de Werneck Maria Departamento de Farmacologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, Av. Lineu Prestes 1524, 05508, São Paulo, Brasil aut Naunyn-Schmiedeberg's Archives of Pharmacology Springer-Verlag 346/4(1992-10-01), 405-409 0028-1298 346:4<405 1992 346 210 https://doi.org/10.1007/BF00171082 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00171082 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Markus Regina Departamento de Farmacologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, Av. Lineu Prestes 1524, 05508, São Paulo, Brasil aut NATIONALLICENCE 700 1- de Werneck Maria Departamento de Farmacologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, Av. Lineu Prestes 1524, 05508, São Paulo, Brasil aut NATIONALLICENCE 773 0- Naunyn-Schmiedeberg's Archives of Pharmacology Springer-Verlag 346/4(1992-10-01), 405-409 0028-1298 346:4<405 1992 346 210 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer