caa a22 4500 469078405 CHVBK 20180323132942.0 cr unu---uuuuu 170328e19921001xx s 000 0 eng 10.1007/BF00171089 doi (NATIONALLICENCE)springer-10.1007/BF00171089 Studies on the effect of two angiotensin-converting enzyme inhibitors, captopril and cilazapril, on platelet and vascular prostaglandin metabolism in vivo [Elektronische Daten] [Brunhilde Wagner, Hans-Georg Eichler, Barbara Schneider, Brigitte Blöchl-Daum, Brigitte Brenner, Slobodan Gasic, Klaus Lechner, Paul Kyrle] Summary: We have studied in 12 healthy volunteers the effects of two angiotensin-converting enzyme (ACE) inhibitors, captopril and cilazapril, on vascular and platelet prostaglandin metabolism, in a double-blind, placebo-controlled, randomized cross-over study. Formation of 6-keto-prostaglandin F1α (6-keto-PGF1α) and thromboxane B2 (TxB2) was measured locally at the site of a microvascular injury. Similar amounts of TxB2 and 6-keto-PGF1α were generated following administration of either ACE inhibitor as compared to placebo. It is concluded that neither captopril nor cilazapril significantly influence vascular and platelet prostaglandin metabolism. Springer-Verlag, 1992 Angiotensin-converting enzyme inhibitors nationallicence Captopril nationallicence Cilazapril nationallicence Thromboxane B2 (TxB2) nationallicence 6-keto-prostaglandin F1α (6-keto-PGF1α) nationallicence ACE : angiotensin-convertin enzyme nationallicence PGI2 : prostacyclin nationallicence TxA2 : thromboxane A2 nationallicence 6-keto-PGF1α : 6-keto-protaglandin nationallicence F1α : TxB2, thromboxane B2 nationallicence Wagner Brunhilde Department of Medicine I, Division of Hematology and Hemostaseology, Austria aut Eichler Hans-Georg Department of Clinical Pharmacology, Austria aut Schneider Barbara Institute of Medical Statistics and Documentation, University of Vienna, Austria aut Blöchl-Daum Brigitte Department of Clinical Pharmacology, Austria aut Brenner Brigitte Department of Medicine I, Division of Hematology and Hemostaseology, Austria aut Gasic Slobodan Department of Clinical Pharmacology, Austria aut Lechner Klaus Department of Medicine I, Division of Hematology and Hemostaseology, Austria aut Kyrle Paul Department of Medicine I, Division of Hematology and Hemostaseology, Austria aut Naunyn-Schmiedeberg's Archives of Pharmacology Springer-Verlag 346/4(1992-10-01), 453-456 0028-1298 346:4<453 1992 346 210 https://doi.org/10.1007/BF00171089 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00171089 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Wagner Brunhilde Department of Medicine I, Division of Hematology and Hemostaseology, Austria aut NATIONALLICENCE 700 1- Eichler Hans-Georg Department of Clinical Pharmacology, Austria aut NATIONALLICENCE 700 1- Schneider Barbara Institute of Medical Statistics and Documentation, University of Vienna, Austria aut NATIONALLICENCE 700 1- Blöchl-Daum Brigitte Department of Clinical Pharmacology, Austria aut NATIONALLICENCE 700 1- Brenner Brigitte Department of Medicine I, Division of Hematology and Hemostaseology, Austria aut NATIONALLICENCE 700 1- Gasic Slobodan Department of Clinical Pharmacology, Austria aut NATIONALLICENCE 700 1- Lechner Klaus Department of Medicine I, Division of Hematology and Hemostaseology, Austria aut NATIONALLICENCE 700 1- Kyrle Paul Department of Medicine I, Division of Hematology and Hemostaseology, Austria aut NATIONALLICENCE 773 0- Naunyn-Schmiedeberg's Archives of Pharmacology Springer-Verlag 346/4(1992-10-01), 453-456 0028-1298 346:4<453 1992 346 210 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer