caa a22 4500 469078448 CHVBK 20180323132942.0 cr unu---uuuuu 170328e19921001xx s 000 0 eng 10.1007/BF00171092 doi (NATIONALLICENCE)springer-10.1007/BF00171092 Feeding but not salt loading is the dominant factor controlling urinary dopamine excretion in conscious rats [Elektronische Daten] [Bernd Mühlbauer, Hartmut Osswald] Summary: We studied urinary dopamine excretion in three different groups of rats after the following treatment regimens: normal chow and tap water (controls, CON), normal chow and 1 % NaCl as drinking water (high salt, HS), and chow with low sodium content plus tap water (low salt, LS). On days 5 and 7 of the respective dietary treatment, rats were placed in metabolic cages. Using a cross over design, chow was given (fed) or withheld (fasted). Urine was collected for 24 h and analyzed for sodium, creatinine, and dopamine. Urinary dopamine excretion did not change in proportion to large differences in sodium excretion in fasted animals. Sodium excretion was enhanced (45%) due to feeding only in the CON group but not in HS and LS rats. However, there was a striking increase in renal dopamine excretion in fed compared to fasted animals, irrespective of their sodium diet: 2.5-fold in CON, 2-fold in HS, and 1.8-fold in LS rats. Urinary creatinine excretion was significantly elevated during the feeding condition compared to fasted animals in all treatment groups. Our results demonstrate that urinary dopamine excretion is dominantly influenced by feeding but not by oral sodium intake in conscious rats. We conclude that (1) the dietary state of the animals should be controlled in experiments on renal dopamine production, (2) renally formed dopamine could be involved in the functional response of the kidney to oral food intake. Springer-Verlag, 1992 Dopamine nationallicence Conscious rats nationallicence Feeding nationallicence Oral sodium load nationallicence Kidney function nationallicence Mühlbauer Bernd Institute of Pharmacology, University of Tubingen, Wilhelmstrasse 56, W-7400, Tubingen, Federal Republic of Germany aut Osswald Hartmut Institute of Pharmacology, University of Tubingen, Wilhelmstrasse 56, W-7400, Tubingen, Federal Republic of Germany aut Naunyn-Schmiedeberg's Archives of Pharmacology Springer-Verlag 346/4(1992-10-01), 469-471 0028-1298 346:4<469 1992 346 210 https://doi.org/10.1007/BF00171092 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00171092 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Mühlbauer Bernd Institute of Pharmacology, University of Tubingen, Wilhelmstrasse 56, W-7400, Tubingen, Federal Republic of Germany aut NATIONALLICENCE 700 1- Osswald Hartmut Institute of Pharmacology, University of Tubingen, Wilhelmstrasse 56, W-7400, Tubingen, Federal Republic of Germany aut NATIONALLICENCE 773 0- Naunyn-Schmiedeberg's Archives of Pharmacology Springer-Verlag 346/4(1992-10-01), 469-471 0028-1298 346:4<469 1992 346 210 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer