caa a22 4500 469078456 CHVBK 20180323132942.0 cr unu---uuuuu 170328e19921001xx s 000 0 eng 10.1007/BF00171087 doi (NATIONALLICENCE)springer-10.1007/BF00171087 Alcohol withdrawal reaction as a result of adaptive changes of excitatory amino acid receptors [Elektronische Daten] [Göran Engberg, Mihály Hajós] Summary: Recent electrophysiological and biochemical studies suggest that ethanol interferes with excitatory amino acid (EAA) neurotransmission. Here, we present electrophysiological evidence that, following cessation of a chronic ethanol treatment, noradrenergic locus coeruleus (LC) neurons display hyperactivity at the same time as a specifically enhanced sensitivity to microiontophoretically applied NMDA or quisqualate. Furthermore, after chronic ethanol treatment, but not before, the NMDA receptor antagonist MK 801 (0.3-2.4 mg/kg, i.v.) dose-dependently inhibited the firing of the LC neurons. Our data indicate that an up-regulation of EAA receptors located on LC neurons accounts for the changes in LC firing in ethanol-treated rats. We propose that activation of the LC contributes to the clinical signs of the ethanol abstinence reaction and that EAA antagonists may be beneficial therapeutically for its treatment. Springer-Verlag, 1992 Locus coeruleus nationallicence Noradrenaline nationallicence NMDA nationallicence Quisqualate nationallicence Kainate nationallicence MK 801 nationallicence Engberg Göran Department of Pharmacology, University of Gothenburg, S-41390, Gothenburg, Sweden aut Hajós Mihály Department of Physiology, A. Szent-Györgyi Medical University, Szeged, Hungary aut Naunyn-Schmiedeberg's Archives of Pharmacology Springer-Verlag 346/4(1992-10-01), 437-441 0028-1298 346:4<437 1992 346 210 https://doi.org/10.1007/BF00171087 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00171087 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Engberg Göran Department of Pharmacology, University of Gothenburg, S-41390, Gothenburg, Sweden aut NATIONALLICENCE 700 1- Hajós Mihály Department of Physiology, A. Szent-Györgyi Medical University, Szeged, Hungary aut NATIONALLICENCE 773 0- Naunyn-Schmiedeberg's Archives of Pharmacology Springer-Verlag 346/4(1992-10-01), 437-441 0028-1298 346:4<437 1992 346 210 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer