caa a22 4500 469078502 CHVBK 20180323132942.0 cr unu---uuuuu 170328e19921101xx s 000 0 eng 10.1007/BF00169017 doi (NATIONALLICENCE)springer-10.1007/BF00169017 Pentylenetetrazol-induced seizures in rats: an ontogenetic study [Elektronische Daten] [L. Velisek, H. Kubova, M. Pohl, L. Stankova, P. Mareš, R. Schickerova] Summary: A quantitative description of motor seizures induced by pentylenetetrazol (PTZ, metrazol) was performed. Seizures were induced by PTZ in doses from 40 to 120 mg/kg s.c. in 477 male albino rats of the Wistar strain 7 to 90 days old. Two patterns of seizures were elicited: minimal, i.e. predominantly clonic seizures of facial and forelimb muscles with preserved righting ability, and major, i.e. generalized tonic-clonic seizures with a loss of righting reflex. Minimal seizures could be reliably elicited since the age of 18 days; the CD50 for these seizures did not significantly differ with age. Major seizures were elicited regularly at all developmental stages studied. Their CD50 did not significantly differ among 7-, 12- and 25-day-old rat pups but the value for 18-day-old rats was smaller and for adult animals larger than for these three age groups. Springer-Verlag, 1992 Seizures nationallicence Pentylenetetrazol nationallicence Development nationallicence Rat nationallicence Velisek L. Institute of Physiology, Czechoslovak Academy of Sciences, Czechoslovakia aut Kubova H. Institute of Physiology, Czechoslovak Academy of Sciences, Czechoslovakia aut Pohl M. Institute of Physiology, Czechoslovak Academy of Sciences, Czechoslovakia aut Stankova L. Institute of Physiology, Czechoslovak Academy of Sciences, Czechoslovakia aut Mareš P. Institute of Physiology, Czechoslovak Academy of Sciences, Czechoslovakia aut Schickerova R. Department of Neurology, Institute for Postgraduate Training of Physicians and Pharmacists, CS-14220, Prague 4, Czechoslovakia aut Naunyn-Schmiedeberg's Archives of Pharmacology Springer-Verlag 346/5(1992-11-01), 588-591 0028-1298 346:5<588 1992 346 210 https://doi.org/10.1007/BF00169017 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00169017 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Velisek L. Institute of Physiology, Czechoslovak Academy of Sciences, Czechoslovakia aut NATIONALLICENCE 700 1- Kubova H. Institute of Physiology, Czechoslovak Academy of Sciences, Czechoslovakia aut NATIONALLICENCE 700 1- Pohl M. Institute of Physiology, Czechoslovak Academy of Sciences, Czechoslovakia aut NATIONALLICENCE 700 1- Stankova L. Institute of Physiology, Czechoslovak Academy of Sciences, Czechoslovakia aut NATIONALLICENCE 700 1- Mareš P. Institute of Physiology, Czechoslovak Academy of Sciences, Czechoslovakia aut NATIONALLICENCE 700 1- Schickerova R. Department of Neurology, Institute for Postgraduate Training of Physicians and Pharmacists, CS-14220, Prague 4, Czechoslovakia aut NATIONALLICENCE 773 0- Naunyn-Schmiedeberg's Archives of Pharmacology Springer-Verlag 346/5(1992-11-01), 588-591 0028-1298 346:5<588 1992 346 210 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer