caa a22 4500 469078553 CHVBK 20180323132942.0 cr unu---uuuuu 170328e19921101xx s 000 0 eng 10.1007/BF00169004 doi (NATIONALLICENCE)springer-10.1007/BF00169004 Stimulation of the nigrostriatal dopamine system inhibits both heat production and heat loss mechanisms in rats [Elektronische Daten] [M. Lin, M. Ho, M. Young] Summary: The effects of stimulating the pars compacta of the substantia nigra (SNC) on thermoregulation were assessed in normal rats, in rats with chemical lesion of the SNC dopamine (DA) pathways and in rats with striatal DA receptor blockade. Electrical stimulation of the SNC produced hypothermia, decreased metabolism and/or cutaneous vasoconstriction in rats at ambient temperatures (T a ) below 22°C, as well as hyperthermia and cutaneous vasoconstriction in rats at T a of 30°C. Microinjection of an excitotoxic amino acid (kainic acid) at the same brain sites also produced the same thermal responses. In vivo voltammetric studies revealed that electrical or chemical stimulation of the SNC produced an increase in striatal DA release. The enhanced striatal DA release induced by SNC stimulation was attenuated in rats after selective destruction of the nigrostriatal DA pathway by administration of 6-hydroxydopamine into the medial forebrain bundle. In addition, the magnitude of the thermal responses produced by the SNC stimulation in the cold was attenuated by selective bilateral destruction of the nigrostriatal DA pathways or selective blockade of the striatal DA produced by intrastriatal infusion of haloperidol, a DA receptor antagonist. The results indicate that stimulation of the SNC inhibits both heat production and heat loss mechanisms in the rat. Springer-Verlag, 1992 Thermoregulation nationallicence Dopamine nationallicence Substantia nigra nationallicence Corpus striatum nationallicence Voltammetry nationallicence Medial forebrain bundle nationallicence Metabolism nationallicence Lin M. Department of Physiology, National Cheng Kung University Medical College, Tainan, Taiwan, Republic of China aut Ho M. Department of Electrical Engineering, National Cheng Kung University, Tainan, Taiwan, Republic of China aut Young M. Department of Electrical Engineering, National Cheng Kung University, Tainan, Taiwan, Republic of China aut Naunyn-Schmiedeberg's Archives of Pharmacology Springer-Verlag 346/5(1992-11-01), 504-510 0028-1298 346:5<504 1992 346 210 https://doi.org/10.1007/BF00169004 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00169004 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Lin M. Department of Physiology, National Cheng Kung University Medical College, Tainan, Taiwan, Republic of China aut NATIONALLICENCE 700 1- Ho M. Department of Electrical Engineering, National Cheng Kung University, Tainan, Taiwan, Republic of China aut NATIONALLICENCE 700 1- Young M. Department of Electrical Engineering, National Cheng Kung University, Tainan, Taiwan, Republic of China aut NATIONALLICENCE 773 0- Naunyn-Schmiedeberg's Archives of Pharmacology Springer-Verlag 346/5(1992-11-01), 504-510 0028-1298 346:5<504 1992 346 210 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer