caa a22 4500 46907857X CHVBK 20180323132942.0 cr unu---uuuuu 170328e19921101xx s 000 0 eng 10.1007/BF00169005 doi (NATIONALLICENCE)springer-10.1007/BF00169005 Pituitary adenylate cyclase activating peptide, a novel VIP-like gut-brain peptide, relaxes the guinea-pig taenia caeci via apamin-sensitive potassium channels [Elektronische Daten] [H. Schwörer, S. Katsoulis, W. Creutzfeldt, W. Schmidt] Summary: Effects of pituitary adenylate cyclase activating peptide (PACAP-(1-27)) and vasoactive intestinal polypeptide (VIP) on the guinea-pig taenia caeci were studied in the presence of guanethidine and scopolamine. Both peptides (1 nmol/1-1 μmol/1) concentration-dependently relaxed the smooth muscle of the taenia. PACAP-(1-27) and VIP were nearly equipotent. Apamin (30 nmol/1), a selective blocker of calcium-activated potassium channels, abolished the relaxation induced by PACAP-(1-27) whereas the effect of VIP remained unaffected. PACAP-(1-27) may be a candidate for the noncholinergic, non-adrenergic inhibitory neurotransmitter which induces apamin-sensitive relaxation in the intestinal tract. Springer-Verlag, 1992 Gastrointestinal tract nationallicence Non-adrenergic nationallicence non-cholinergic transmitter nationallicence PACAP receptors nationallicence Smooth muscle nationallicence Guinea-pig taenia caeci nationallicence Schwörer H. Department of Medicine, Division of Gastroenterology and Endocrinology, University of Göttingen, Robert-Koch-Strasse 40, W-3400, Göttingen, Federal Republic of Germany aut Katsoulis S. Department of Medicine, Division of Gastroenterology and Endocrinology, University of Göttingen, Robert-Koch-Strasse 40, W-3400, Göttingen, Federal Republic of Germany aut Creutzfeldt W. Department of Medicine, Division of Gastroenterology and Endocrinology, University of Göttingen, Robert-Koch-Strasse 40, W-3400, Göttingen, Federal Republic of Germany aut Schmidt W. Department of Medicine, Division of Gastroenterology and Endocrinology, University of Göttingen, Robert-Koch-Strasse 40, W-3400, Göttingen, Federal Republic of Germany aut Naunyn-Schmiedeberg's Archives of Pharmacology Springer-Verlag 346/5(1992-11-01), 511-514 0028-1298 346:5<511 1992 346 210 https://doi.org/10.1007/BF00169005 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00169005 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Schwörer H. Department of Medicine, Division of Gastroenterology and Endocrinology, University of Göttingen, Robert-Koch-Strasse 40, W-3400, Göttingen, Federal Republic of Germany aut NATIONALLICENCE 700 1- Katsoulis S. Department of Medicine, Division of Gastroenterology and Endocrinology, University of Göttingen, Robert-Koch-Strasse 40, W-3400, Göttingen, Federal Republic of Germany aut NATIONALLICENCE 700 1- Creutzfeldt W. Department of Medicine, Division of Gastroenterology and Endocrinology, University of Göttingen, Robert-Koch-Strasse 40, W-3400, Göttingen, Federal Republic of Germany aut NATIONALLICENCE 700 1- Schmidt W. Department of Medicine, Division of Gastroenterology and Endocrinology, University of Göttingen, Robert-Koch-Strasse 40, W-3400, Göttingen, Federal Republic of Germany aut NATIONALLICENCE 773 0- Naunyn-Schmiedeberg's Archives of Pharmacology Springer-Verlag 346/5(1992-11-01), 511-514 0028-1298 346:5<511 1992 346 210 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer