caa a22 4500 469078588 CHVBK 20180323132942.0 cr unu---uuuuu 170328e19921101xx s 000 0 eng 10.1007/BF00169001 doi (NATIONALLICENCE)springer-10.1007/BF00169001 5-Hydroxytryptamine increases contractile force in porcine right atrium but not in left ventricle [Elektronische Daten] [Regien Schoemaker, Xiao Du, Willem Bax, Pramod Saxena] Summary: Positive chronotropic as well as inotropic effects of 5-hydroxytryptamine (5-HT) have been observed in pig artial tissue, but no data are available about the direct effects of 5-HT on ventricular tissue. In the present study we investigated inotropic effects of 5-HT on atrial and ventricular trabeculae obtained from hearts of 3 months old pigs. The baseline isometric contractile force was significantly higher in ventricular (4.14±1.25 mN) than in atrial tissue (0.47±0.11 mN). A noradrenaline concentration-response curve (0.01 to 10 μmol/l) was used to check contractile responsiveness of the tissue and all responses were expressed as percentage of the response to 10 μmol/l noradrenaline. Noradrenaline caused a concentration-dependent increase in contractile force in both atrial and ventricular trabeculae. In contrast, though 5-HT (0.01 to 100 μmol/l) did increase force of contraction in atrial tissue (maximum: 72±20% of the response to noradrenaline 10 μmol/l), the contractility of ventricular trabeculae was not significantly affected (maximum: 12±6%). The present data show that, in contrast to atrial tissue, contractile force of ventricular tissue could not be significantly affected by 5-HT To our knowledge, this is the first study to show that an agent which increased force of contraction in the atrium, did not have a corresponding effect on the ventricle. These findings may have important implications for a better understanding of the physiology and pharmacology of cardiac contractility. Springer-Verlag, 1992 Atrium nationallicence Contractile force nationallicence 5-Hydroxytryptamine nationallicence Ventricle nationallicence Schoemaker Regien Department of Pharmacology, Faculty of Medicine and Health Sciences, Erasmus University Rotterdam, Post Box 1738, NL-3000, DR Rotterdam, The Netherlands aut Du Xiao Department of Pharmacology, Faculty of Medicine and Health Sciences, Erasmus University Rotterdam, Post Box 1738, NL-3000, DR Rotterdam, The Netherlands aut Bax Willem Department of Pharmacology, Faculty of Medicine and Health Sciences, Erasmus University Rotterdam, Post Box 1738, NL-3000, DR Rotterdam, The Netherlands aut Saxena Pramod Department of Pharmacology, Faculty of Medicine and Health Sciences, Erasmus University Rotterdam, Post Box 1738, NL-3000, DR Rotterdam, The Netherlands aut Naunyn-Schmiedeberg's Archives of Pharmacology Springer-Verlag 346/5(1992-11-01), 486-489 0028-1298 346:5<486 1992 346 210 https://doi.org/10.1007/BF00169001 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00169001 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Schoemaker Regien Department of Pharmacology, Faculty of Medicine and Health Sciences, Erasmus University Rotterdam, Post Box 1738, NL-3000, DR Rotterdam, The Netherlands aut NATIONALLICENCE 700 1- Du Xiao Department of Pharmacology, Faculty of Medicine and Health Sciences, Erasmus University Rotterdam, Post Box 1738, NL-3000, DR Rotterdam, The Netherlands aut NATIONALLICENCE 700 1- Bax Willem Department of Pharmacology, Faculty of Medicine and Health Sciences, Erasmus University Rotterdam, Post Box 1738, NL-3000, DR Rotterdam, The Netherlands aut NATIONALLICENCE 700 1- Saxena Pramod Department of Pharmacology, Faculty of Medicine and Health Sciences, Erasmus University Rotterdam, Post Box 1738, NL-3000, DR Rotterdam, The Netherlands aut NATIONALLICENCE 773 0- Naunyn-Schmiedeberg's Archives of Pharmacology Springer-Verlag 346/5(1992-11-01), 486-489 0028-1298 346:5<486 1992 346 210 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer